Low expression of DNA polymerase beta in human testicular germ cell tumours--impact on foetal gonocytic origin theory.

Abstract:

Different models of pathogenesis of adult testicular germ cell tumours (TGCTs) are presented. Analysis of telomeric length and DNA polymerase beta expression suggests that seminoma and nonseminoma, two main histological types of TGCTs, derive independently from transformed foetal primordial cells.

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