Effects of gypenosides on mouse splenic lymphocyte transformation and DNA polymerase II activity in vitro.

Liao DF, Lu N, Lei LS, Yu L, Chen JX
Zhongguo Yao Li Xue Bao (1995), Volume 16, Page 322
PubMed entry

Abstract:

AIM: To study the effects of gypenosides (Gyp) on lymphocyte ...
AIM: To study the effects of gypenosides (Gyp) on lymphocyte transformation and DNA polymerase II activity. METHODS: Lymphocyte transformation response was induced by concanavalin A and lipopolysaccharides respectively. The activity of DNA polymerase II and DNA synthesis were assayed with TTP and [3H]TdR incorporation respectively in mixed lymphocyte culture test. RESULTS: Gyp 2.5-20 mg L-1 enhanced splenic T- and B- cell transformation, increased the DNA synthesis and potentiated the activity of DNA polymerase II. However, Gyp > 40 mg L-1 showed contrary effects. CONCLUSION: Gyp regulated lymphocyte transformation and DNA synthesis by regulating DNA polymerase II activity.

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