[A study of the proliferative activity of DNA polymerase alpha immunoreactivity in breast cancer].

Nishimura R, Nagao K, Matsuda M, Baba K, Matsuoka Y, Ueno Y, Morinaga H, Nagase H, Miyayama O, Hamada T
Gan No Rinsho (1989), Volume 35, Page 1417
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Abstract:

DNA polymerase alpha activity is associated with cell proliferation, ...
DNA polymerase alpha activity is associated with cell proliferation, independently of the cell cycle phase, and a simple and reproducible method for the immunohistochemical demonstration of DNA polymerase alpha has been developed. In an analysis of a total of 76 human breast cancer tissues using this procedure, the clinico-pathological findings revealed that only the estrogen receptor (ER) significantly correlated with the DNA polymerase alpha activity. Therefore, this suggests that ER-negative tumors had a higher proliferative activity.

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