Inactivation of bacteriophage T4 by ethyl methanesulfonate: influence of host and viral genotypes.

Abstract:

Inactivation of bacteriophage T4 by ethyl methanesulfonate (EMS) is a complex process which depends critically upon the conditions of treatment and upon both the viral and the host genotypes. EMS-inactivated particles are capable of multiplicity and cross-reactivation, indicating the need for caution in using EMS in certain types of mutation studies. The pyrimidine dimer excision systems of the phage and the host do not affect the EMS sensitivity of T4, but the T4x(+)y(+) system does. Mutational defects in the deoxyribonucleic acid (DNA) ligase and the DNA polymerase systems both of the virus and of its host also affect viral EMS sensitivity.

Polymerases:

Topics:

Modulators/Inhibitors

One line summary:

T4 pol is implicated in the control of bacteriophage T4's ethyl methanesulfonate sensitivity.

Note:

This paper reports survival rates of T4 ts mutants in EMS treatment.

Status:

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