Trisodium phosphonoformate inhibits hepatitis B Dane particle DNA polymerase.

Nordenfelt E, Helgstrand E, Oberg B
Acta Pathol Microbiol Scand B (1979), Volume 87B, Page 75
PubMed entry

Abstract:

Evidence available indicates that the so-called Dane particles are the ...
Evidence available indicates that the so-called Dane particles are the hepatitis virus. A DNA polymerase is associated with the core of these particles. The probability that this is the viral DNA polymerase offers the possibility of preventing hepatitis B multiplication by selective inhibition of this enzyme. This investigation reports that trisodium phosphonoformate (PFA) at low concentrations but not phosphonoacetate acid (PAA) inhitits Dane particle associated DNA polymerase.

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