Induction of spleen cell growth and DNA polymerase activity by Corynebacterium parvum.

Maruyama Y, Coleman MS
Cancer research (1978), Volume 38, Page 1617
PubMed entry


Corynebacterium parvum induces rapid proliferation of spleen cells ...
Corynebacterium parvum induces rapid proliferation of spleen cells with concomitant rapid increases in DNA synthesis as measured by [3H]thymidine uptake and increase in DNA polymerase activity. Cell number increased exponentially over 10 days. DNA polymerase activity increased 8-fold after C. parvum stimulation. The rapidity of response indicated a population response to the stimulus, and the data are consistent with a direct stimulation of spleen cell proliferation by C. parvum.




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