Mutator mutations in bacteriophage T4 gene 42 (dHMC hydroxymethylase).


Temperature-sensitive mutations of bacteriophage T4 gene 42 produce ...
Temperature-sensitive mutations of bacteriophage T4 gene 42 produce diverse effects upon spontaneous mutation rate. G:C vector A:T transition rates are increased, often strongly; frameshift mutation rates are weakly increased; A:T vector G:C transition rates (and perhaps also A:T vector Py:Pu transversion rates) are decreased; and one G:C vector Py:Pu transversion rate is also decreased. These results, together with certain interactions between gene-42 mutator effects and both base analogue mutagenesis and the viral error-prone repair system, suggest that the dHMC hydroxymethylase coded by gene 42 affects mutation rates in a more complex manner than by the simple regulation of the concentration of the DNA precursor dHMCTP.




Mutational Analysis, Fidelity, Accessory Proteins/Complexes

One line summary:

Temperature sensitive mutations of gp42 can results in an increase of mutations, most notably G:C to A:T mutations being significantly increased while A:T to G:C mutations being weakly increased


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