Synthetic studies on kohamaic acids: synthesis of structurally simplified analogs of kohamaic acid A.

Takikawa H, Kamatani N, Nakanishi K, Tashiro T, Sasaki M, Yoshida H, Mizushina Y
Bioscience, biotechnology, and biochemistry (2008), Volume 72, Page 3071
PubMed entry

Abstract:

Kohamaic acid A is a potent DNA polymerase inhibitor isolated from the ...
Kohamaic acid A is a potent DNA polymerase inhibitor isolated from the Okinawan marine sponge Ircinia sp. A series of structurally simplified analogs of kohamaic acid A were synthesized with the aim of evaluating structure-activity relationships.

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