Analysis of DNA methylation status of the promoter of human telomerase reverse transcriptase in gastric carcinogenesis.


Telomerase is expressed in normal somatic cells and reactivated in majority of tumor cells. Human telomerase reverse transcriptase (hTERT), a catalytic subunit of telomerase, is a rate-limiting factor of telomerase activity. Evidence has shown that gastric cancer is the result of genetics and epignomics. DNA methylation is one of the most important research fields in epigenomics. It is one of the mechanisms resulting in gene silencing in carcinogenesis.




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