DNA polymerase ι of mammals as a participant in translesion synthesis of DNA.

Gening LV
Biochemistry. Biokhimii͡a (2011), Volume 76, Page 61
PubMed entry

Abstract:

This review describes the properties of some specialized DNA ...
This review describes the properties of some specialized DNA polymerases participating in translesion synthesis of DNA. Special attention is given to these properties in vivo. DNA polymerase iota (Polι) of mammals has very unusual features and is extremely error-prone. Based on available data, a hypothesis is proposed explaining how mammalian cells can explore the unusual features of DNA Polι to bypass DNA damages and to simultaneously prevent its mutagenic potential.

Polymerases:

Human Pol iota

Topics:

Nucleotide Analogs / Template Lesions

Status:

new topics/pols set partial results complete validated

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Version:20240415

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