Expression changes in DNA repair enzymes and mitochondrial DNA damage in aging rat lens.

Zhang Y, Zhang L, Zhang L, Bai J, Ge H, Liu P
Molecular vision (2010), Volume 16, Page 1754
PubMed entry Full article text

Abstract:

To determine if there is increased mitochondrial DNA (mtDNA) and ...
To determine if there is increased mitochondrial DNA (mtDNA) and nuclear DNA (nDNA) damage with age in the lenses of rats. We also explored the immunolocalization of 8-oxoguanine DNA glycosylase 1 (OGG1) and AP endonuclease 1 (APE1) in the lens and studied three of the predominant base excision repair (BER) enzymes: OGG1, APE1, and DNA polymerase gamma (Polgamma).

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