Development of noninvasive prenatal diagnosis of trisomy 21 by RT-MLPA with a new set of SNP markers.

Li PQ, Zhang J, Fan JH, Zhang YZ, Hou HY
Archives of gynecology and obstetrics (2013)
PubMed entry Publisher's site

Abstract:

Placental mRNA can now be detected in maternal whole blood, raising ...
Placental mRNA can now be detected in maternal whole blood, raising the possibility of using maternal blood for noninvasive prenatal diagnosis (NIPD) of trisomy 21. We aimed to identify new mRNA-single nucleotide polymorphism (mRNA-SNP) markers suitable for use in reverse-transcriptase multiplex ligation-dependent probe amplification (RT-MLPA) to develop a more reliable diagnostic method for trisomy 21 in Chinese subjects.

Polymerases:

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Topics:

Health/Disease, Nucleotide Analogs / Template Lesions, RNase H Activity

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Authors: Hong-Ying Hou

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