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Stuart DI

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Publications:

Title Authors Year Journal
Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 2. Stuart DI 2004 J Med Chem
Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1. Stuart DI 2004 J Med Chem
Cloning, expression, purification, and crystallisation of HIV-2 reverse transcriptase. Stuart DI 2003 Protein expression and purification
Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215. Stuart DI 2002 J Virol
Structure of HIV-2 reverse transcriptase at 2.35-A resolution and the mechanism of resistance to non-nucleoside inhibitors. Stuart DI 2002 Proceedings of the National Academy of Sciences of the United States of America
A functional and structural basis for TCR cross-reactivity in multiple sclerosis. Stuart DI 2002 Nat Immunol
2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1. Stuart DI 2001 J Med Chem
Structural mechanisms of drug resistance for mutations at codons 181 and 188 in HIV-1 reverse transcriptase and the improved resilience of second generation non-nucleoside inhibitors. Stuart DI 2001 Journal of molecular biology
Structural basis for the resilience of efavirenz (DMP-266) to drug resistance mutations in HIV-1 reverse transcriptase. Stuart DI 2000 Structure (London, England : 1993)
Binding of the second generation non-nucleoside inhibitor S-1153 to HIV-1 reverse transcriptase involves extensive main chain hydrogen bonding. Stuart DI 2000 The Journal of biological chemistry
Phenylethylthiazolylthiourea (PETT) non-nucleoside inhibitors of HIV-1 and HIV-2 reverse transcriptases. Structural and biochemical analyses. Stuart DI 2000 The Journal of biological chemistry
Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants. Stuart DI 1999 J Med Chem
A family of insertion mutations between codons 67 and 70 of human immunodeficiency virus type 1 reverse transcriptase confer multinucleoside analog resistance. Stuart DI 1999 Antimicrob Agents Chemother
Crystallographic analysis of the binding modes of thiazoloisoindolinone non-nucleoside inhibitors to HIV-1 reverse transcriptase and comparison with modeling studies. Stuart DI 1999 J Med Chem
3'-Azido-3'-deoxythymidine drug resistance mutations in HIV-1 reverse transcriptase can induce long range conformational changes. Stuart DI 1998 Proceedings of the National Academy of Sciences of the United States of America
Crystal structures of HIV-1 reverse transcriptase in complex with carboxanilide derivatives. Stuart DI 1998 Biochemistry
Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor. Stuart DI 1997 Proceedings of the National Academy of Sciences of the United States of America
Models which explain the inhibition of reverse transcriptase by HIV-1-specific (thio)carboxanilide derivatives. Stuart DI 1997 Biochemical and biophysical research communications
Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors. Stuart DI 1996 J Med Chem
High resolution structures of HIV-1 RT from four RT-inhibitor complexes. Stuart DI 1995 Nat Struct Biol
The structure of HIV-1 reverse transcriptase complexed with 9-chloro-TIBO: lessons for inhibitor design. Stuart DI 1995 Structure (London, England : 1993)
Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors. Stuart DI 1995 Nat Struct Biol
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