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Schinazi RF

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Publications:

Title Authors Year Journal
Balancing Antiviral Potency and Host Toxicity: Identifying a Nucleotide Inhibitor with an Optimal Kinetic Phenotype for HIV-1 Reverse Transcriptase. Schinazi RF 2012 Molecular pharmacology
Exploiting the anti-HIV-1 activity of acyclovir: suppression of primary and drug-resistant HIV isolates and potentiation of the activity by ribavirin. Schinazi RF 2012 Antimicrobial agents and chemotherapy
Substrate mimicry: HIV-1 reverse transcriptase recognizes 6-modified-3'-azido-2',3'-dideoxyguanosine-5'-triphosphates as adenosine analogs. Schinazi RF 2011 Nucleic acids research
Mechanisms associated with HIV-1 resistance to acyclovir by the V75I mutation in reverse transcriptase. Schinazi RF 2009 The Journal of biological chemistry
Engineering of a chimeric RB69 DNA polymerase sensitive to drugs targeting the cytomegalovirus enzyme. Schinazi RF 2009 The Journal of biological chemistry
Acyclovir is activated into a HIV-1 reverse transcriptase inhibitor in herpesvirus-infected human tissues. Schinazi RF 2008 Cell Host Microbe
Delayed chain termination protects the anti-hepatitis B virus drug entecavir from excision by HIV-1 reverse transcriptase. Schinazi RF 2008 The Journal of biological chemistry
D- and L-2',3'-didehydro-2',3'-dideoxy-3'-fluoro-carbocyclic nucleosides: synthesis, anti-HIV activity and mechanism of resistance. Schinazi RF 2007 Journal of medicinal chemistry
Interaction of 2'-deoxyguanosine triphosphate analogue inhibitors of HIV reverse transcriptase with human mitochondrial DNA polymerase gamma. Schinazi RF 2007 Antivir Chem Chemother
The 3'-azido group is not the primary determinant of 3'-azido-3'-deoxythymidine (AZT) responsible for the excision phenotype of AZT-resistant HIV-1. Schinazi RF 2005 The Journal of biological chemistry
Relationship between antiviral activity and host toxicity: comparison of the incorporation efficiencies of 2',3'-dideoxy-5-fluoro-3'-thiacytidine-triphosphate analogs by human immunodeficiency virus type 1 reverse transcriptase and human mitochondrial DNA polymerase. Schinazi RF 2004 Antimicrobial agents and chemotherapy
Investigating the effects of stereochemistry on incorporation and removal of 5-fluorocytidine analogs by mitochondrial DNA polymerase gamma: comparison of D- and L-D4FC-TP. Schinazi RF 2004 Antiviral Res
HIV-1 resistance profile of the novel nucleoside reverse transcriptase inhibitor beta-D-2',3'-dideoxy-2',3'-didehydro-5-fluorocytidine (Reverset). Schinazi RF 2003 Antiviral chemistry & chemotherapy
Probing the molecular mechanisms of AZT drug resistance mediated by HIV-1 reverse transcriptase using a transient kinetic analysis. Schinazi RF 2003 Biochemistry
Probing the mechanistic consequences of 5-fluorine substitution on cytidine nucleotide analogue incorporation by HIV-1 reverse transcriptase. Schinazi RF 2003 Antivir Chem Chemother
Virulence and reduced fitness of simian immunodeficiency virus with the M184V mutation in reverse transcriptase. Schinazi RF 2002 Journal of virology
Mechanism of action of 1-beta-D-2,6-diaminopurine dioxolane, a prodrug of the human immunodeficiency virus type 1 inhibitor 1-beta-D-dioxolane guanosine. Schinazi RF 2001 Antimicrobial agents and chemotherapy
Differential removal of thymidine nucleotide analogues from blocked DNA chains by human immunodeficiency virus reverse transcriptase in the presence of physiological concentrations of 2'-deoxynucleoside triphosphates. Schinazi RF 2000 Antimicrob Agents Chemother
In vitro selection of mutations in the human immunodeficiency virus type 1 reverse transcriptase that decrease susceptibility to (-)-beta-D-dioxolane-guanosine and suppress resistance to 3'-azido-3'-deoxythymidine. Schinazi RF 2000 Antimicrobial agents and chemotherapy
Stavudine resistance: an update on susceptibility following prolonged therapy. Schinazi RF 1999 Antiviral therapy
Synthesis and biological evaluation of 2',3'-didehydro-2',3'- dideoxy-5-fluorocytidine (D4FC) analogues: discovery of carbocyclic nucleoside triphosphates with potent inhibitory activity against HIV-1 reverse transcriptase. Schinazi RF 1999 J Med Chem
A new point mutation (P157S) in the reverse transcriptase of human immunodeficiency virus type 1 confers low-level resistance to (-)-beta-2',3'-dideoxy-3'-thiacytidine. Schinazi RF 1999 Antimicrobial agents and chemotherapy
In vitro anti-HIV activity of biflavonoids isolated from Rhus succedanea and Garcinia multiflora. Schinazi RF 1997 Journal of natural products
Comparative kinetic analyses of interaction of inhibitors with Rauscher murine leukemia virus and human immunodeficiency virus reverse transcriptases. Schinazi RF 1996 Antimicrob Agents Chemother
Novel mutations in reverse transcriptase of human immunodeficiency virus type 1 reduce susceptibility to foscarnet in laboratory and clinical isolates. Schinazi RF 1995 Antimicrob Agents Chemother
Anti-human immunodeficiency virus activities of the beta-L enantiomer of 2',3'-dideoxycytidine and its 5-fluoro derivative in vitro. Schinazi RF 1994 Antimicrobial agents and chemotherapy
Resistance of human immunodeficiency virus type 1 to acyclic 6-phenylselenenyl- and 6-phenylthiopyrimidines. Schinazi RF 1994 Antimicrobial agents and chemotherapy
Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides. Schinazi RF 1993 Antimicrob Agents Chemother
Comparison of inhibitory activities of various antiretroviral agents against particle-derived and recombinant human immunodeficiency virus type 1 reverse transcriptases. Schinazi RF 1989 Antimicrobial agents and chemotherapy
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