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Gu Z

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Title Authors Year Journal
Selection of resistance-conferring mutations in HIV-1 by the nucleoside reverse transcriptase inhibitors (+/-)dOTC and (+/-)dOTFC. Gu Z 2000 Antiviral chemistry & chemotherapy
Mechanism of action and in vitro activity of 1',3'-dioxolanylpurine nucleoside analogues against sensitive and drug-resistant human immunodeficiency virus type 1 variants. Gu Z 1999 Antimicrobial agents and chemotherapy
Endogenous reverse transcriptase assays reveal synergy between combinations of the M184V and other drug resistance-conferring mutations in interactions with nucleoside analog triphosphates. Gu Z 1998 Journal of molecular biology
The K65R mutation confers increased DNA polymerase processivity to HIV-1 reverse transcriptase. Gu Z 1996 The Journal of biological chemistry
In vitro selection and molecular characterization of human immunodeficiency virus type 1 with reduced sensitivity to 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA). Gu Z 1996 Antiviral research
Endogenous reverse transcription assays reveal high-level resistance to the triphosphate of (-)2'-dideoxy-3'-thiacytidine by mutated M184V human immunodeficiency virus type 1. Gu Z 1996 J Virol
Effectiveness of 3TC in HIV clinical trials may be due in part to the M184V substitution in 3TC-resistant HIV-1 reverse transcriptase. Gu Z 1996 AIDS (London, England)
Resistance to (-)-2',3'-dideoxy-3'-thiacytidine (3TC) in HIV-1 isolated from paediatric patients. Gu Z 1996 Antiviral therapy
Studies of neutralizing monoclonal antibody to human immunodeficiency virus type 1 reverse transcriptase: antagonistic and synergistic effects in reactions performed in the presence of nucleoside and nonnucleoside inhibitors, respectively. Gu Z 1996 Journal of virology
Enhanced fidelity of 3TC-selected mutant HIV-1 reverse transcriptase. Gu Z 1996 Science (New York, N.Y.)
Single-step purification of recombinant wild-type and mutant HIV-1 reverse transcriptase. Gu Z 1996 Protein expression and purification
Effects of 3'-deoxynucleoside 5'-triphosphate concentrations on chain termination by nucleoside analogs during human immunodeficiency virus type 1 reverse transcription of minus-strand strong-stop DNA. Gu Z 1996 Journal of virology
Development of HIV-1 resistance to (-)2'-deoxy-3'-thiacytidine in patients with AIDS or advanced AIDS-related complex. Gu Z 1995 AIDS (London, England)
Mutated K65R recombinant reverse transcriptase of human immunodeficiency virus type 1 shows diminished chain termination in the presence of 2',3'-dideoxycytidine 5'-triphosphate and other drugs. Gu Z 1995 Proceedings of the National Academy of Sciences of the United States of America
[Molecular basis and clinical significance of HIV-1 resistance to nucleoside compounds]. Gu Z 1995 Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie
Effects of non-nucleoside inhibitors of human immunodeficiency virus type 1 in cell-free recombinant reverse transcriptase assays. Gu Z 1995 The Journal of biological chemistry
Inhibition of human immunodeficiency virus type 1 multiplication by transforming growth factor beta 1 and AZT in HIV-1-infected myeloid cells. Gu Z 1995 Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
K65R mutation of human immunodeficiency virus type 1 reverse transcriptase encodes cross-resistance to 9-(2-phosphonylmethoxyethyl)adenine. Gu Z 1995 Antimicrobial agents and chemotherapy
Targeting HIV reverse transcriptase in novel ways. Gu Z 1995 Nature medicine
Comparison of deoxyoligonucleotide and tRNA(Lys-3) as primers in an endogenous human immunodeficiency virus-1 in vitro reverse transcription/template-switching reaction. Gu Z 1994 The Journal of biological chemistry
Identification of novel mutations that confer drug resistance in the human immunodeficiency virus polymerase gene. Gu Z 1994 Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K
Identification of a mutation at codon 65 in the IKKK motif of reverse transcriptase that encodes human immunodeficiency virus resistance to 2',3'-dideoxycytidine and 2',3'-dideoxy-3'-thiacytidine. Gu Z 1994 Antimicrobial agents and chemotherapy
The K65R mutant reverse transcriptase of HIV-1 cross-resistant to 2', 3'-dideoxycytidine, 2',3'-dideoxy-3'-thiacytidine, and 2',3'-dideoxyinosine shows reduced sensitivity to specific dideoxynucleoside triphosphate inhibitors in vitro. Gu Z 1994 The Journal of biological chemistry
Comparison of cord blood and peripheral blood mononuclear cells as targets for viral isolation and drug sensitivity studies involving human immunodeficiency virus type 1. Gu Z 1994 Journal of clinical microbiology
Clinical correlates and molecular basis of HIV drug resistance. Gu Z 1993 Journal of acquired immune deficiency syndromes
The same mutation that encodes low-level human immunodeficiency virus type 1 resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine confers high-level resistance to the (-) enantiomer of 2',3'-dideoxy-3'-thiacytidine. Gu Z 1993 Antimicrob Agents Chemother
Novel mutation in the human immunodeficiency virus type 1 reverse transcriptase gene that encodes cross-resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine. Gu Z 1992 J Virol
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