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Kodama EN

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Publications:

Title Authors Year Journal
Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA. Kodama EN 2013 Retrovirology
HIV-1 reverse transcriptase (RT) polymorphism 172K, suppresses the effect of clinically relevant drug resistance mutations to both nucleoside and nonnucleoside RT inhibitors. Kodama EN 2012 The Journal of biological chemistry
The N348I mutation at the connection subdomain of HIV-1 reverse transcriptase decreases binding to nevirapine. Kodama EN 2010 The Journal of biological chemistry
SC29EK, a peptide fusion inhibitor with enhanced alpha-helicity, inhibits replication of human immunodeficiency virus type 1 mutants resistant to enfuvirtide. Kodama EN 2009 Antimicrobial agents and chemotherapy
Design of peptide-based inhibitors for human immunodeficiency virus type 1 strains resistant to T-20. Kodama EN 2009 The Journal of biological chemistry
2'-deoxy-4'-C-ethynyl-2-halo-adenosines active against drug-resistant human immunodeficiency virus type 1 variants. Kodama EN 2008 The international journal of biochemistry & cell biology
Amino acid mutation N348I in the connection subdomain of human immunodeficiency virus type 1 reverse transcriptase confers multiclass resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors. Kodama EN 2008 J Virol
Activity against human immunodeficiency virus type 1, intracellular metabolism, and effects on human DNA polymerases of 4'-ethynyl-2-fluoro-2'-deoxyadenosine. Kodama EN 2007 Antimicrob Agents Chemother
2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine: a nucleoside reverse transcriptase inhibitor with highly potent activity against all HIV-1 strains, favorable toxic profiles and stability in plasma. Kodama EN 2006 Nucleic Acids Symp Ser (Oxf)
Attempt to reduce cytotoxicity by synthesizing the L-enantiomer of 4'-C-ethynyl-2'-deoxypurine nucleosides as antiviral agents against HIV and HBV. Kodama EN 2004 Antivir Chem Chemother
Design, efficient synthesis, and anti-HIV activity of 4'-C-cyano- and 4'-C-ethynyl-2'-deoxy purine nucleosides. Kodama EN 2004 Nucleosides, nucleotides & nucleic acids
Interactions of conformationally biased north and south 2'-fluoro-2', 3'-dideoxynucleoside 5'-triphosphates with the active site of HIV-1 reverse transcriptase. Kodama EN 2000 Biochemistry
In vitro induction of human immunodeficiency virus type 1 variants resistant to phosphoralaninate prodrugs of Z-methylenecyclopropane nucleoside analogues. Kodama EN 1999 Antimicrobial agents and chemotherapy
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