2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine: a nucleoside reverse transcriptase inhibitor with highly potent activity against all HIV-1 strains, favorable toxic profiles and stability in plasma.

Ohrui H, Kohgo S, Hayakawa H, Kodama EN, Matsuoka M, Nakata T, Mitsuya H
Nucleic Acids Symp Ser (Oxf) (2006), Volume , Page 1
PubMed entry Publisher's site

Abstract:

A working hypothesis to solve the critical problems of existing HAART ...
A working hypothesis to solve the critical problems of existing HAART was proposed. The study based on the hypothesis proved the validity of the hypothesis and resulted in the development of 2'-deoxy-4'-C-ethynyl-2-fluoro-adenosine (4'Ed2FA), a nucleoside reverse transcriptase inhibitor (NRTI) with highly potent activity against all HIV-1 strains, very favourable toxic profiles, and stability in plasma.

Polymerases:

HIV RT

Topics:

Reverse Transcriptase

Status:

new topics/pols set partial results complete validated

Results:

Polymerase Reference Property Result Context
HIV RT 2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine: a nucleoside reverse transcriptase inhibitor with highly potent activity against all HIV-1 strains, favorable toxic profiles and stability in plasma. Reverse Transcriptase Activity Yes
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Version:20240415

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