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Grindley ND

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Publications:

Title Authors Year Journal
Conformational landscapes of DNA polymerase I and mutator derivatives establish fidelity checkpoints for nucleotide insertion. Grindley ND 2013 Nature communications
Distinct roles of the active-site Mg2+ ligands, Asp882 and Asp705, of DNA polymerase I (Klenow fragment) during the prechemistry conformational transitions. Grindley ND 2011 The Journal of biological chemistry
Conformational transitions in DNA polymerase I revealed by single-molecule FRET. Grindley ND 2010 Proceedings of the National Academy of Sciences of the United States of America
Fingers-closing and other rapid conformational changes in DNA polymerase I (Klenow fragment) and their role in nucleotide selectivity. Grindley ND 2008 Biochemistry
Conformational changes during normal and error-prone incorporation of nucleotides by a Y-family DNA polymerase detected by 2-aminopurine fluorescence. Grindley ND 2007 Biochemistry
DNA polymerase catalysis in the absence of Watson-Crick hydrogen bonds: analysis by single-turnover kinetics. Grindley ND 2006 Biochemistry
The properties of steric gate mutants reveal different constraints within the active sites of Y-family and A-family DNA polymerases. Grindley ND 2006 The Journal of biological chemistry
Interaction of DNA polymerase I (Klenow fragment) with the single-stranded template beyond the site of synthesis. Grindley ND 2003 Biochemistry
Use of 2-aminopurine fluorescence to examine conformational changes during nucleotide incorporation by DNA polymerase I (Klenow fragment). Grindley ND 2003 Biochemistry
An error-prone family Y DNA polymerase (DinB homolog from Sulfolobus solfataricus) uses a 'steric gate' residue for discrimination against ribonucleotides. Grindley ND 2003 Nucleic acids research
Discrimination against purine-pyrimidine mispairs in the polymerase active site of DNA polymerase I: a structural explanation. Grindley ND 2002 Proceedings of the National Academy of Sciences of the United States of America
The mutational specificity of the Dbh lesion bypass polymerase and its implications. Grindley ND 2002 The Journal of biological chemistry
Contacts between the 5' nuclease of DNA polymerase I and its DNA substrate. Grindley ND 2001 The Journal of biological chemistry
Coordination between the polymerase and 5'-nuclease components of DNA polymerase I of Escherichia coli. Grindley ND 2000 The Journal of biological chemistry
A single side chain prevents Escherichia coli DNA polymerase I (Klenow fragment) from incorporating ribonucleotides. Grindley ND 1998 Proceedings of the National Academy of Sciences of the United States of America
How E. coli DNA polymerase I (Klenow fragment) distinguishes between deoxy- and dideoxynucleotides. Grindley ND 1998 Journal of molecular biology
Biochemical and mutational studies of the 5'-3' exonuclease of DNA polymerase I of Escherichia coli. Grindley ND 1997 Journal of molecular biology
Deoxynucleoside triphosphate and pyrophosphate binding sites in the catalytically competent ternary complex for the polymerase reaction catalyzed by DNA polymerase I (Klenow fragment). Grindley ND 1995 The Journal of biological chemistry
Side chains involved in catalysis of the polymerase reaction of DNA polymerase I from Escherichia coli. Grindley ND 1992 The Journal of biological chemistry
Reactions at the polymerase active site that contribute to the fidelity of Escherichia coli DNA polymerase I (Klenow fragment). Grindley ND 1992 The Journal of biological chemistry
The 3'-5' exonuclease of DNA polymerase I of Escherichia coli: contribution of each amino acid at the active site to the reaction. Grindley ND 1991 The EMBO journal
Identification of residues critical for the polymerase activity of the Klenow fragment of DNA polymerase I from Escherichia coli. Grindley ND 1990 The Journal of biological chemistry
Genetic mapping and DNA sequence analysis of mutations in the polA gene of Escherichia coli. Grindley ND 1985 Journal of molecular biology
Method for determining whether a gene of Escherichia coli is essential: application to the polA gene. Grindley ND 1984 J Bacteriol
Construction of a plasmid that overproduces the large proteolytic fragment (Klenow fragment) of DNA polymerase I of Escherichia coli. Grindley ND 1983 Proceedings of the National Academy of Sciences of the United States of America
Nucleotide sequence of the Escherichia coli polA gene and primary structure of DNA polymerase I. Grindley ND 1982 The Journal of biological chemistry
polA6, A mutation affecting the DNA binding capacity of DNA polymerase I. Grindley ND 1976 Nucleic acids research
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