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Ling H

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Publications:

Title Authors Year Journal
Replication of a carcinogenic nitropyrene DNA lesion by human Y-family DNA polymerase. Ling H 2013 Nucleic acids research
Structural mechanism of ribonucleotide discrimination by a Y-family DNA polymerase. Ling H 2011 Journal of molecular biology
Structural insight into dynamic bypass of the major cisplatin-DNA adduct by Y-family polymerase Dpo4. Ling H 2010 The EMBO journal
Structural basis of error-prone replication and stalling at a thymine base by human DNA polymerase iota. Ling H 2009 The EMBO journal
Structural insight into recruitment of translesion DNA polymerase Dpo4 to sliding clamp PCNA. Ling H 2009 Molecular microbiology
Snapshots of a Y-family DNA polymerase in replication: substrate-induced conformational transitions and implications for fidelity of Dpo4. Ling H 2008 Journal of molecular biology
A structural gap in Dpo4 supports mutagenic bypass of a major benzo[a]pyrene dG adduct in DNA through template misalignment. Ling H 2007 Proceedings of the National Academy of Sciences of the United States of America
Mechanism of template-independent nucleotide incorporation catalyzed by a template-dependent DNA polymerase. Ling H 2007 Journal of molecular biology
Fidelity of Dpo4: effect of metal ions, nucleotide selection and pyrophosphorolysis. Ling H 2005 The EMBO journal
Investigating the role of the little finger domain of Y-family DNA polymerases in low fidelity synthesis and translesion replication. Ling H 2004 The Journal of biological chemistry
Crystal structure of a benzo[a]pyrene diol epoxide adduct in a ternary complex with a DNA polymerase. Ling H 2004 Proceedings of the National Academy of Sciences of the United States of America
Snapshots of replication through an abasic lesion; structural basis for base substitutions and frameshifts. Ling H 2004 Molecular cell
Replication of a cis-syn thymine dimer at atomic resolution. Ling H 2003 Nature
Structure-based interpretation of missense mutations in Y-family DNA polymerases and their implications for polymerase function and lesion bypass. Ling H 2002 DNA repair
Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein. Ling H 2001 The EMBO journal
Crystal structure of a Y-family DNA polymerase in action: a mechanism for error-prone and lesion-bypass replication. Ling H 2001 Cell

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