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Hwang CB

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Publications:

Title Authors Year Journal
Finger domain mutation affects enzyme activity, DNA replication efficiency, and fidelity of an exonuclease-deficient DNA polymerase of herpes simplex virus type 1. Hwang CB 2009 J Virol
The enhanced DNA replication fidelity of a mutant herpes simplex virus type 1 DNA polymerase is mediated by an improved nucleotide selectivity and reduced mismatch extension ability. Hwang CB 2008 J Virol
Herpes simplex virus mutants with multiple substitutions affecting DNA binding of UL42 are impaired for viral replication and DNA synthesis. Hwang CB 2007 Journal of virology
Mutations that decrease DNA binding of the processivity factor of the herpes simplex virus DNA polymerase reduce viral yield, alter the kinetics of viral DNA replication, and decrease the fidelity of DNA replication. Hwang CB 2007 J Virol
Effects of substitutions of arginine residues on the basic surface of herpes simplex virus UL42 support a role for DNA binding in processive DNA synthesis. Hwang CB 2005 Journal of virology
A point mutation within conserved region VI of herpes simplex virus type 1 DNA polymerase confers altered drug sensitivity and enhances replication fidelity. Hwang CB 2004 J Virol
The enzymological basis for resistance of herpesvirus DNA polymerase mutants to acyclovir: relationship to the structure of alpha-like DNA polymerases. Hwang CB 1999 Proceedings of the National Academy of Sciences of the United States of America
Effects of exonuclease activity and nucleotide selectivity of the herpes simplex virus DNA polymerase on the fidelity of DNA replication in vivo. Hwang CB 1999 J Virol
Effects of mutations in the Exo III motif of the herpes simplex virus DNA polymerase gene on enzyme activities, viral replication, and replication fidelity. Hwang CB 1997 J Virol
An altered spectrum of herpes simplex virus mutations mediated by an antimutator DNA polymerase. Hwang CB 1995 Gene
Structural and functional organization of herpes simplex virus DNA polymerase investigated by limited proteolysis. Hwang CB 1994 The Journal of biological chemistry
A point mutation within a distinct conserved region of the herpes simplex virus DNA polymerase gene confers drug resistance. Hwang CB 1992 Journal of virology
Engineered herpes simplex virus DNA polymerase point mutants: the most highly conserved region shared among alpha-like DNA polymerases is involved in substrate recognition. Hwang CB 1990 J Virol
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