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Egli M

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Publications:

Title Authors Year Journal
Kinetics, structure, and mechanism of 8-Oxo-7,8-dihydro-2'-deoxyguanosine bypass by human DNA polymerase η. Egli M 2014 The Journal of biological chemistry
Ring-opening of the γ-OH-PdG adduct promotes error-free bypass by the Sulfolobus solfataricus DNA polymerase Dpo4. Egli M 2013 Chemical research in toxicology
Leukotriene biosynthesis inhibitor MK886 impedes DNA polymerase activity. Egli M 2013 Chemical research in toxicology
A nucleotide analogue induced gain of function corrects the error-prone nature of human DNA polymerase iota. Egli M 2012 Journal of the American Chemical Society
A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ. Egli M 2012 PloS one
Differential Furanose Selection in the Active Sites of Archaeal DNA Polymerases Probed by Fixed-Conformation Nucleotide Analogues. Egli M 2012 Biochemistry
Replication bypass of the trans-4-Hydroxynonenal-derived (6S,8R,11S)-1,N(2)-deoxyguanosine DNA adduct by the sulfolobus solfataricus DNA polymerase IV. Egli M 2012 Chemical research in toxicology
Bypass of Aflatoxin B(1) Adducts by the Sulfolobus solfataricus DNA Polymerase IV. Egli M 2011 Journal of the American Chemical Society
Structural basis for proficient incorporation of dTTP opposite O6-methylguanine by human DNA polymerase iota. Egli M 2010 The Journal of biological chemistry
Metal-ion dependence of the active-site conformation of the translesion DNA polymerase Dpo4 from Sulfolobus solfataricus. Egli M 2010 Acta Crystallogr Sect F Struct Biol Cryst Commun
Selective modulation of DNA polymerase activity by fixed-conformation nucleoside analogues. Egli M 2010 Angewandte Chemie (International ed. in English)
Versatility of Y-family Sulfolobus solfataricus DNA polymerase Dpo4 in translesion synthesis past bulky N2-alkylguanine adducts. Egli M 2009 The Journal of biological chemistry
Structural and functional analysis of Sulfolobus solfataricus Y-family DNA polymerase Dpo4-catalyzed bypass of the malondialdehyde-deoxyguanosine adduct. Egli M 2009 Biochemistry
Structural and functional elucidation of the mechanism promoting error-prone synthesis by human DNA polymerase kappa opposite the 7,8-dihydro-8-oxo-2'-deoxyguanosine adduct. Egli M 2009 The Journal of biological chemistry
Structure-function relationships in miscoding by Sulfolobus solfataricus DNA polymerase Dpo4: guanine N2,N2-dimethyl substitution produces inactive and miscoding polymerase complexes. Egli M 2009 The Journal of biological chemistry
Insertion of dNTPs opposite the 1,N2-propanodeoxyguanosine adduct by Sulfolobus solfataricus P2 DNA polymerase IV. Egli M 2008 Biochemistry
Structure and activity of Y-class DNA polymerase DPO4 from Sulfolobus solfataricus with templates containing the hydrophobic thymine analog 2,4-difluorotoluene. Egli M 2007 The Journal of biological chemistry
Sulfolobus solfataricus DNA polymerase Dpo4 is partially inhibited by "wobble" pairing between O6-methylguanine and cytosine, but accurate bypass is preferred. Egli M 2007 The Journal of biological chemistry
Molecular basis of selectivity of nucleoside triphosphate incorporation opposite O6-benzylguanine by sulfolobus solfataricus DNA polymerase Dpo4: steady-state and pre-steady-state kinetics and x-ray crystallography of correct and incorrect pairing. Egli M 2007 The Journal of biological chemistry
Hydrogen bonding of 7,8-dihydro-8-oxodeoxyguanosine with a charged residue in the little finger domain determines miscoding events in Sulfolobus solfataricus DNA polymerase Dpo4. Egli M 2007 The Journal of biological chemistry
Efficient and high fidelity incorporation of dCTP opposite 7,8-dihydro-8-oxodeoxyguanosine by Sulfolobus solfataricus DNA polymerase Dpo4. Egli M 2006 The Journal of biological chemistry
Calcium is a cofactor of polymerization but inhibits pyrophosphorolysis by the Sulfolobus solfataricus DNA polymerase Dpo4. Egli M 2006 Biochemistry
DNA adduct bypass polymerization by Sulfolobus solfataricus DNA polymerase Dpo4: analysis and crystal structures of multiple base pair substitution and frameshift products with the adduct 1,N2-ethenoguanine. Egli M 2005 The Journal of biological chemistry
Structural origins of the exonuclease resistance of a zwitterionic RNA. Egli M 1999 Proceedings of the National Academy of Sciences of the United States of America
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