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Hopkins AL

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Publications:

Title Authors Year Journal
Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 2. Hopkins AL 2004 J Med Chem
Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1. Hopkins AL 2004 J Med Chem
Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants. Hopkins AL 1999 J Med Chem
Crystallographic analysis of the binding modes of thiazoloisoindolinone non-nucleoside inhibitors to HIV-1 reverse transcriptase and comparison with modeling studies. Hopkins AL 1999 J Med Chem
Crystal structures of HIV-1 reverse transcriptase in complex with carboxanilide derivatives. Hopkins AL 1998 Biochemistry
3'-Azido-3'-deoxythymidine drug resistance mutations in HIV-1 reverse transcriptase can induce long range conformational changes. Hopkins AL 1998 Proceedings of the National Academy of Sciences of the United States of America
Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor. Hopkins AL 1997 Proceedings of the National Academy of Sciences of the United States of America
Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors. Hopkins AL 1996 J Med Chem
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