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Borkow G

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Publications:

Title Authors Year Journal
The thiocarboxanilide nonnucleoside inhibitor UC781 restores antiviral activity of 3'-azido-3'-deoxythymidine (AZT) against AZT-resistant human immunodeficiency virus type 1. Borkow G 1999 Antimicrobial agents and chemotherapy
Phenotypic mechanism of HIV-1 resistance to 3'-azido-3'-deoxythymidine (AZT): increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase. Borkow G 1998 Biochemistry
Physicochemical and biochemical properties of 2',5'-linked RNA and 2',5'-RNA:3',5'-RNA "hybrid" duplexes. Borkow G 1998 Biochemistry
Inhibition of toxic activities of Bothrops asper venom and other crotalid snake venoms by a novel neutralizing mixture. Borkow G 1997 Toxicol Appl Pharmacol
The thiocarboxanilide nonnucleoside UC781 is a tight-binding inhibitor of HIV-1 reverse transcriptase. Borkow G 1997 Biochemistry
Inhibitory potency of R-region specific antisense oligonucleotides against in vitro DNA polymerization and template-switching reactions catalysed by HIV-1 reverse transcriptase. Borkow G 1997 Int J Biochem Cell Biol
Inhibition of the hemorrhagic activity of Bothrops asper venom by a novel neutralizing mixture. Borkow G 1997 Toxicon
Chemical barriers to human immunodeficiency virus type 1 (HIV-1) infection: retrovirucidal activity of UC781, a thiocarboxanilide nonnucleoside inhibitor of HIV-1 reverse transcriptase. Borkow G 1997 J Virol
Inhibition of the ribonuclease H and DNA polymerase activities of HIV-1 reverse transcriptase by N-(4-tert-butylbenzoyl)-2-hydroxy-1-naphthaldehyde hydrazone. Borkow G 1997 Biochemistry
Differences in the inhibition of human immunodeficiency virus type 1 reverse transcriptase DNA polymerase activity by analogs of nevirapine and [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5"-(4"-amino-1", 2"-oxathiole-2",2"-dioxide] (TSAO). Borkow G 1996 Molecular pharmacology
The K65R mutation confers increased DNA polymerase processivity to HIV-1 reverse transcriptase. Borkow G 1996 The Journal of biological chemistry
Effectiveness of 3TC in HIV clinical trials may be due in part to the M184V substitution in 3TC-resistant HIV-1 reverse transcriptase. Borkow G 1996 AIDS (London, England)
Enhanced fidelity of 3TC-selected mutant HIV-1 reverse transcriptase. Borkow G 1996 Science (New York, N.Y.)
Single-step purification of recombinant wild-type and mutant HIV-1 reverse transcriptase. Borkow G 1996 Protein expression and purification
Synergistic inhibition of HIV-1 reverse transcriptase DNA polymerase activity and virus replication in vitro by combinations of carboxanilide nonnucleoside compounds. Borkow G 1995 Biochemistry
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