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Perno CF

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Publications:

Title Authors Year Journal
A Multi-targeted Drug Candidate with Dual Anti-HIV and Anti-HSV Activity. Perno CF 2013 PLoS pathogens
Topical tenofovir, a microbicide effective against HIV, inhibits herpes simplex virus-2 replication. Perno CF 2011 Cell host & microbe
Effect of the human immunodeficiency virus type 1 reverse transcriptase polymorphism Leu-214 on replication capacity and drug susceptibility. Perno CF 2009 Journal of virology
Therapeutic strategies towards HIV-1 infection in macrophages. Perno CF 2006 Antiviral research
Involvement of novel human immunodeficiency virus type 1 reverse transcriptase mutations in the regulation of resistance to nucleoside inhibitors. Perno CF 2006 Journal of virology
Accuracy, precision, and consistency of expert HIV type 1 genotype interpretation: an international comparison (The GUESS Study). Perno CF 2005 Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
High sequence conservation of human immunodeficiency virus type 1 reverse transcriptase under drug pressure despite the continuous appearance of mutations. Perno CF 2005 Journal of virology
The role of Thr139 in the human immunodeficiency virus type 1 reverse transcriptase sensitivity to (+)-calanolide A. Perno CF 2005 Molecular pharmacology
The N137 and P140 amino acids in the p51 and the P95 amino acid in the p66 subunit of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase are instrumental to maintain catalytic activity and to design new classes of anti-HIV-1 drugs. Perno CF 2005 FEBS letters
The amino acid Asn136 in HIV-1 reverse transcriptase (RT) maintains efficient association of both RT subunits and enables the rational design of novel RT inhibitors. Perno CF 2005 Molecular pharmacology
Antiviral profile of HIV inhibitors in macrophages: implications for therapy. Perno CF 2004 Current topics in medicinal chemistry
Macrophages and HIV infection: therapeutical approaches toward this strategic virus reservoir. Perno CF 2002 Antiviral research
Exploitation of the low fidelity of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase and the nucleotide composition bias in the HIV-1 genome to alter the drug resistance development of HIV. Perno CF 2001 Journal of virology
Presence of 2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5"-(4"-amino-1",2"-oxath iole-2",2"-dioxide) (TSAO)-resistant virus strains in TSAO-inexperienced HIV patients. Perno CF 2000 AIDS research and human retroviruses
Inhibition of replication of HIV in primary monocyte/macrophages by different antiviral drugs and comparative efficacy in lymphocytes. Perno CF 1997 Journal of leukocyte biology
Highly favorable antiviral activity and resistance profile of the novel thiocarboxanilide pentenyloxy ether derivatives UC-781 and UC-82 as inhibitors of human immunodeficiency virus type 1 replication. Perno CF 1996 Molecular pharmacology
Potent inhibition of human immunodeficiency virus and herpes simplex virus type 1 by 9-(2-phosphonylmethoxyethyl)adenine in primary macrophages is determined by drug metabolism, nucleotide pools, and cytokines. Perno CF 1996 Molecular pharmacology
Selective inhibition of HIV replication by adriamycin in macrophages but not in lymphocytes. Perno CF 1992 AIDS research and human retroviruses
2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2'-dioxide)pyrimidine (TSAO) nucleoside analogues: highlyselective inhibitors of human immunodeficiency virus type 1 that are targeted at the viral reverse transcriptase. Perno CF 1992 Proceedings of the National Academy of Sciences of the United States of America
Potent DNA chain termination activity and selective inhibition of human immunodeficiency virus reverse transcriptase by 2',3'-dideoxyuridine-5'-triphosphate. Perno CF 1990 Molecular pharmacology
Highly specific inhibition of human immunodeficiency virus type 1 by a novel 6-substituted acyclouridine derivative. Perno CF 1989 Biochemical and biophysical research communications
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