Effect of the human immunodeficiency virus type 1 reverse transcriptase polymorphism Leu-214 on replication capacity and drug susceptibility.

Puertas MC, Buzón MJ, Artese A, Alcaro S, Menéndez-Arias L, Perno CF, Clotet B, Ceccherini-Silberstein F, Martinez-Picado J
Journal of virology (2009), Volume 83, Page 7434
PubMed entry Full article text Publisher's site

Abstract:

A negative association between polymorphism Leu-214 and type-1 ...
A negative association between polymorphism Leu-214 and type-1 thymidine analogue mutations (TAM1) and a positive association with a clinically favorable virological response to thymidine analogue-based combination antiretroviral therapy have been described. In this study, the impact of Leu-214 on replication capacity and resistance to zidovudine (ZDV) of viruses containing TAM1 or TAM2 was determined. Leu-214 decreased the growth rate of viruses bearing Tyr-215, as well as their resistance to ZDV. This observation was confirmed by structural and molecular modeling data, suggesting a regulatory role for Leu-214 in the emergence and phenotypic resistance of TAM1.

Polymerases:

HIV RT

Topics:

Mutational Analysis, Health/Disease

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