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Velázquez S

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Publications:

Title Authors Year Journal
N-3 substituted TSAO derivatives as a probe to explore the dimeric interface of HIV-1 reverse transcriptase. Velázquez S Nucleosides, nucleotides & nucleic acids
4"-Benzoylureido-TSAO derivatives as potent and selective non-nucleoside HCMV inhibitors. Structure-activity relationship and mechanism of antiviral action. Velázquez S 2008 Journal of medicinal chemistry
Novel non-nucleoside human cytomegalovirus inhibitors based upon TSAO nucleoside derivatives: structure-activity relationships. Velázquez S 2007 Nucleosides, nucleotides & nucleic acids
Dimerization inhibitors of HIV-1 reverse transcriptase, protease and integrase: a single mode of inhibition for the three HIV enzymes? Velázquez S 2006 Antiviral research
TSAO derivatives, inhibitors of HIV-1 reverse transcriptase dimerization: recent progress. Velázquez S 2006 Current pharmaceutical design
The amino acid Asn136 in HIV-1 reverse transcriptase (RT) maintains efficient association of both RT subunits and enables the rational design of novel RT inhibitors. Velázquez S 2005 Molecular pharmacology
The role of Thr139 in the human immunodeficiency virus type 1 reverse transcriptase sensitivity to (+)-calanolide A. Velázquez S 2005 Molecular pharmacology
The N137 and P140 amino acids in the p51 and the P95 amino acid in the p66 subunit of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase are instrumental to maintain catalytic activity and to design new classes of anti-HIV-1 drugs. Velázquez S 2005 FEBS letters
TSAO derivatives the first non-peptide inhibitors of HIV-1 RT dimerization. Velázquez S 2005 Antiviral chemistry & chemotherapy
TSAO compounds: the comprehensive story of a unique family of HIV-1 specific inhibitors of reverse transcriptase. Velázquez S 2004 Current topics in medicinal chemistry
Structure-activity relationship studies on a novel family of specific HIV-1 reverse transcriptase inhibitors. Velázquez S 2003 Antiviral chemistry & chemotherapy
Synthesis of 3' '-substituted TSAO derivatives with anti-HIV-1 and anti-HIV-2 activity through an efficient palladium-catalyzed cross-coupling approach. Velázquez S 2002 Journal of medicinal chemistry
Identification of a putative binding site for [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)thymine (TSAO) derivatives at the p51-p66 interface of HIV-1 reverse transcriptase. Velázquez S 2001 Journal of medicinal chemistry
Identification of a novel family of nucleosides that specifically inhibit HIV-1 reverse transcriptase. Velázquez S 2001 Bioorganic & medicinal chemistry letters
Exploitation of the low fidelity of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase and the nucleotide composition bias in the HIV-1 genome to alter the drug resistance development of HIV. Velázquez S 2001 Journal of virology
Site-directed mutagenesis of human immunodeficiency virus type 1 reverse transcriptase at amino acid position 138. Velázquez S 2001 Virology
Potential multifunctional inhibitors of HIV-1 reverse transcriptase. Novel [AZT]-[TSAO-T] and [d4T]-[TSAO-T] heterodimers modified in the linker and in the dideoxynucleoside region. Velázquez S 1999 Journal of medicinal chemistry
Abasic analogues of TSAO-T as the first sugar derivatives that specifically inhibit HIV-1 reverse transcriptase. Velázquez S 1998 Journal of medicinal chemistry
Synthesis and anti-HIV activity of [AZT]-[TSAO-T] and [AZT]-[HEPT] dimers as potential multifunctional inhibitors of HIV-1 reverse transcriptase. Velázquez S 1995 Journal of medicinal chemistry
Resistance of HIV-1 reverse transcriptase against [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2''-dioxide)] (TSAO) derivatives is determined by the mutation Glu138-->Lys on the p51 subunit. Velázquez S 1994 The Journal of biological chemistry
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