Identification of a novel family of nucleosides that specifically inhibit HIV-1 reverse transcriptase.

Chamorro C, Lobatón E, Bonache MC, De Clercq E, Balzarini J, Velázquez S, San-Félix A, Camarasa MJ
Bioorganic & medicinal chemistry letters (2001), Volume 11, Page 3085
PubMed entry

Abstract:

N-3-Benzyloxycarbonylmethyl- and N-3-carboxymethyl-TBDMS-substituted ...
N-3-Benzyloxycarbonylmethyl- and N-3-carboxymethyl-TBDMS-substituted nucleosides were synthesized and evaluated for activity against HIV replication. It was found that the N-3-carboxymethyl-TBDMS-substituted nucleosides were specific inhibitors of HIV-1 replication. They should be considered as members of a novel and original class of NNRTIs.

Polymerases:

HIV RT

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