Identification of a novel family of nucleosides that specifically inhibit HIV-1 reverse transcriptase.


N-3-Benzyloxycarbonylmethyl- and N-3-carboxymethyl-TBDMS-substituted ...
N-3-Benzyloxycarbonylmethyl- and N-3-carboxymethyl-TBDMS-substituted nucleosides were synthesized and evaluated for activity against HIV replication. It was found that the N-3-carboxymethyl-TBDMS-substituted nucleosides were specific inhibitors of HIV-1 replication. They should be considered as members of a novel and original class of NNRTIs.




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