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Welcome to the Polymerase Page

This page presents all the information in Polbase for HIV RT V108I.


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Mutant of: HIV RT (V108I)

HIV RT V108I is a family RT enzyme from HIV. From the Los Alamos National Labs HIV Mutant database (now offline):|id:430|codon:GTA>ATA|drugs:ADAMII|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:6.74-fold. Tested against a site-directed mutant. "From the Los Alamos National Labs HIV Mutant database (now offline):|id:431|codon:GTA>ATA|drugs:BI-RG-587 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:432|codon:GTA>ATA|drugs:DMP-266 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:433|codon:GTA>GCA|drugs:L-697 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:434|codon:GTA>ATA|drugs:LY-300046 HCl "From the Los Alamos National Labs HIV Mutant database (now offline):|id:437|codon:GTA >ATA|drugs:UC-781|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:By passage 10: 55-fold-R

Selected Properties for HIV RT V108I:

3'-5' exo activity 5'-3' exo activity Frameshift Rate Substitution Rate General Error Rate
no data no data no data no data no data
Year Authors Title Results by property
2004 Jingshan Ren, Charles E Nichols, Phillip P Chamberlain, Kurt L Weaver, Steven A Short, David K Stammers Crystal structures of HIV-1 reverse t... Associated condition,All properties
2000 L T Bacheler, E D Anton, P Kudish, D Baker, J Bunville, K Krakowski, L Bolling, M Aujay, X V Wang, D Ellis, M F Becker, A L Lasut, H J George, D R Spalding, G Hollis, K Abremski Human immunodeficiency virus type 1 m...
1998 Mark Cushman, A Casimiro-Garcia, E Hejchman, J A Ruell, M Huang, C A Schaeffer, K Williamson, W G Rice, Robert W Buckheit New alkenyldiarylmethanes with enhanc...
1997 Robert W Buckheit, M J Snow, V Fliakas-Boltz, T L Kinjerski, J D Russell, L A Pallansch, W G Brouwer, S S Yang Highly potent oxathiin carboxanilide ...
1996 D L Winslow, S Garber, C Reid, H Scarnati, D Baker, M M Rayner, E D Anton Selection conditions affect the evolu...
1995 Haijiang Zhang, L Vrang, K Bäckbro, P Lind, Christer Sahlberg, Torsten Unge, Bo Oberg Inhibition of human immunodeficiency ...
1994 Douglas D Richman, D Havlir, J Corbeil, D Looney, C Ignacio, S A Spector, J Sullivan, S Cheeseman, K Barringer, D Pauletti Nevirapine resistance mutations of hu...
1993 V W Byrnes, V V Sardana, W A Schleif, J H Condra, J A Waterbury, J A Wolfgang, W J Long, C L Schneider, A J Schlabach, B S Wolanski Comprehensive mutant enzyme and viral...

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