Selection conditions affect the evolution of specific mutations in the reverse transcriptase gene associated with resistance to DMP 266.

Winslow DL, Garber S, Reid C, Scarnati H, Baker D, Rayner MM, Anton ED
AIDS (London, England) (1996), Volume 10, Page 1205
PubMed entry

Abstract:

To monitor the appearance of HIV-1 variants resistant to inhibition by ...
To monitor the appearance of HIV-1 variants resistant to inhibition by DMP 266, a benzoxazinone non-nucleoside reverse transcriptase inhibitor using two different protocols for applying drug selective pressure in tissue culture. To compare the phenotype and genotype of viral isolates selected by each method.

Polymerases:

HIV RT L100I,HIV RT V108I,HIV RT V179D,HIV RT Y181C,HIV RT

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