Motors and switches: AAA+ machines within the replisome.

Abstract:

Clamp loaders are required to load the ring-shaped clamps that tether replicative DNA polymerases onto DNA. Recently solved crystal structures, along with a series of biochemical studies, have provided a detailed understanding of the clamp loading reaction. In particular, studies of the Escherichia coli clamp loader--an AAA+ machine--have provided insights into the architecture of clamp loaders from eukaryotes, bacteriophage T4 and archaea. Other AAA+ proteins are also involved in the initiation of DNA replication, and studies of the E. coli clamp loader indicate mechanisms by which these proteins might function.

Polymerases:

T4

Topics:

Historical Protein Properties (MW, pI, ...), Other Enzymatic Activities, Accessory Proteins/Complexes

Status:

new topics/pols set partial results complete validated

Results:

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