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O'Donnell ME

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Publications:

Title Authors Year Journal
A solution to release twisted DNA during chromosome replication by coupled DNA polymerases. O'Donnell ME 2013 Nature
RecA acts as a switch to regulate polymerase occupancy in a moving replication fork. O'Donnell ME 2013 Proceedings of the National Academy of Sciences of the United States of America
A structural role for the PHP domain in E. coli DNA polymerase III. O'Donnell ME 2013 BMC structural biology
Preferential D-loop extension by a translesion DNA polymerase underlies error-prone recombination. O'Donnell ME 2013 Nature structural & molecular biology
How a DNA polymerase clamp loader opens a sliding clamp. O'Donnell ME 2011 Science (New York, N.Y.)
A single subunit directs the assembly of the Escherichia coli DNA sliding clamp loader. O'Donnell ME 2010 Structure (London, England : 1993)
A slow ATP-induced conformational change limits the rate of DNA binding but not the rate of beta clamp binding by the escherichia coli gamma complex clamp loader. O'Donnell ME 2009 The Journal of biological chemistry
Involvement of the beta clamp in methyl-directed mismatch repair in vitro. O'Donnell ME 2009 The Journal of biological chemistry
Mechanism of polymerase collision release from sliding clamps on the lagging strand. O'Donnell ME 2009 The EMBO journal
Translesion DNA polymerases remodel the replisome and alter the speed of the replicative helicase. O'Donnell ME 2009 Proceedings of the National Academy of Sciences of the United States of America
The mechanism of ATP-dependent primer-template recognition by a clamp loader complex. O'Donnell ME 2009 Cell
Structure of a small-molecule inhibitor of a DNA polymerase sliding clamp. O'Donnell ME 2008 Proceedings of the National Academy of Sciences of the United States of America
Structure of a sliding clamp on DNA. O'Donnell ME 2008 Cell
DNA polymerase delta is highly processive with proliferating cell nuclear antigen and undergoes collision release upon completing DNA. O'Donnell ME 2008 The Journal of biological chemistry
A function for the psi subunit in loading the Escherichia coli DNA polymerase sliding clamp. O'Donnell ME 2007 The Journal of biological chemistry
Characterization of a triple DNA polymerase replisome. O'Donnell ME 2007 Molecular cell
Replisome fate upon encountering a leading strand block and clearance from DNA by recombination proteins. O'Donnell ME 2007 The Journal of biological chemistry
Replisome mechanics: insights into a twin DNA polymerase machine. O'Donnell ME 2007 Trends Microbiol
The replication factor C clamp loader requires arginine finger sensors to drive DNA binding and proliferating cell nuclear antigen loading. O'Donnell ME 2006 The Journal of biological chemistry
Crystal structure of a DNA polymerase sliding clamp from a Gram-positive bacterium. O'Donnell ME 2006 BMC Struct Biol
Crystal structure of the catalytic alpha subunit of E. coli replicative DNA polymerase III. O'Donnell ME 2006 Cell
DNA polymerase clamp loaders and DNA recognition. O'Donnell ME 2005 FEBS letters
Mapping the interaction of DNA with the Escherichia coli DNA polymerase clamp loader complex. O'Donnell ME 2005 Nature structural & molecular biology
Structural analysis of the inactive state of the Escherichia coli DNA polymerase clamp-loader complex. O'Donnell ME 2004 Proceedings of the National Academy of Sciences of the United States of America
Protein trafficking on sliding clamps. O'Donnell ME 2004 Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Mechanism of loading the Escherichia coli DNA polymerase III sliding clamp: I. Two distinct activities for individual ATP sites in the gamma complex. O'Donnell ME 2004 The Journal of biological chemistry
Mechanism of loading the Escherichia coli DNA polymerase III sliding clamp: II. Uncoupling the beta and DNA binding activities of the gamma complex. O'Donnell ME 2004 The Journal of biological chemistry
Fluorescence measurements on the E.coli DNA polymerase clamp loader: implications for conformational changes during ATP and clamp binding. O'Donnell ME 2004 Journal of molecular biology
Crystal structure of the chi:psi sub-assembly of the Escherichia coli DNA polymerase clamp-loader complex. O'Donnell ME 2004 Eur J Biochem
Increased dNTP binding affinity reveals a nonprocessive role for Escherichia coli beta clamp with DNA polymerase IV. O'Donnell ME 2004 The Journal of biological chemistry
Nucleotide-induced conformational changes in an isolated Escherichia coli DNA polymerase III clamp loader subunit. O'Donnell ME 2003 Structure (London, England : 1993)
Competitive processivity-clamp usage by DNA polymerases during DNA replication and repair. O'Donnell ME 2003 The EMBO journal
Mechanism of loading the Escherichia coli DNA polymerase III beta sliding clamp on DNA. Bona fide primer/templates preferentially trigger the gamma complex to hydrolyze ATP and load the clamp. O'Donnell ME 2003 The Journal of biological chemistry
Mechanism of the delta wrench in opening the beta sliding clamp. O'Donnell ME 2003 The Journal of biological chemistry
A peptide switch regulates DNA polymerase processivity. O'Donnell ME 2003 Proceedings of the National Academy of Sciences of the United States of America
Fidelity of Escherichia coli DNA polymerase IV. Preferential generation of small deletion mutations by dNTP-stabilized misalignment. O'Donnell ME 2002 The Journal of biological chemistry
Clamp loaders and sliding clamps. O'Donnell ME 2002 Current opinion in structural biology
Motors and switches: AAA+ machines within the replisome. O'Donnell ME 2002 Nature reviews. Molecular cell biology
Analysis of a multicomponent thermostable DNA polymerase III replicase from an extreme thermophile. O'Donnell ME 2002 The Journal of biological chemistry
Resolving a fidelity paradox: why Escherichia coli DNA polymerase II makes more base substitution errors in AT- compared with GC-rich DNA. O'Donnell ME 2002 The Journal of biological chemistry
Mechanism of processivity clamp opening by the delta subunit wrench of the clamp loader complex of E. coli DNA polymerase III. O'Donnell ME 2001 Cell
Clamp loader structure predicts the architecture of DNA polymerase III holoenzyme and RFC. O'Donnell ME 2001 Current biology : CB
Crystal structure of the processivity clamp loader gamma (gamma) complex of E. coli DNA polymerase III. O'Donnell ME 2001 Cell
The ring-type polymerase sliding clamp family. O'Donnell ME 2001 Genome biology
Interaction of the beta sliding clamp with MutS, ligase, and DNA polymerase I. O'Donnell ME 2001 Proceedings of the National Academy of Sciences of the United States of America
Mechanism of beta clamp opening by the delta subunit of Escherichia coli DNA polymerase III holoenzyme. O'Donnell ME 2001 The Journal of biological chemistry
Interplay of clamp loader subunits in opening the beta sliding clamp of Escherichia coli DNA polymerase III holoenzyme. O'Donnell ME 2001 The Journal of biological chemistry
A model for SOS-lesion-targeted mutations in Escherichia coli. O'Donnell ME 2001 Nature
The DNA replication machine of a gram-positive organism. O'Donnell ME 2000 The Journal of biological chemistry
Cross-utilization of the beta sliding clamp by replicative polymerases of evolutionary divergent organisms. O'Donnell ME 2000 The Journal of biological chemistry
Crystal structure of the DNA polymerase processivity factor of T4 bacteriophage. O'Donnell ME 2000 Journal of molecular biology
Fidelity of eucaryotic DNA polymerase delta holoenzyme from Schizosaccharomyces pombe. O'Donnell ME 2000 The Journal of biological chemistry
The delta subunit of DNA polymerase III holoenzyme serves as a sliding clamp unloader in Escherichia coli. O'Donnell ME 2000 The Journal of biological chemistry
Dynamics of beta and proliferating cell nuclear antigen sliding clamps in traversing DNA secondary structure. O'Donnell ME 2000 The Journal of biological chemistry
DNA structure requirements for the Escherichia coli gamma complex clamp loader and DNA polymerase III holoenzyme. O'Donnell ME 2000 The Journal of biological chemistry
A model for Escherichia coli DNA polymerase III holoenzyme assembly at primer/template ends. DNA triggers a change in binding specificity of the gamma complex clamp loader. O'Donnell ME 2000 The Journal of biological chemistry
Molecular mechanism and energetics of clamp assembly in Escherichia coli. The role of ATP hydrolysis when gamma complex loads beta on DNA. O'Donnell ME 2000 The Journal of biological chemistry
UmuD'(2)C is an error-prone DNA polymerase, Escherichia coli pol V. O'Donnell ME 1999 Proceedings of the National Academy of Sciences of the United States of America
The internal workings of a DNA polymerase clamp-loading machine. O'Donnell ME 1999 The EMBO journal
Multiple competition reactions for RPA order the assembly of the DNA polymerase delta holoenzyme. O'Donnell ME 1999 The EMBO journal
Trading places on DNA--a three-point switch underlies primer handoff from primase to the replicative DNA polymerase. O'Donnell ME 1999 Cell
Division of labor--sequential ATP hydrolysis drives assembly of a DNA polymerase sliding clamp around DNA. O'Donnell ME 1999 The EMBO journal
Studies on the interactions between human replication factor C and human proliferating cell nuclear antigen. O'Donnell ME 1999 Proceedings of the National Academy of Sciences of the United States of America
Replisome assembly at oriC, the replication origin of E. coli, reveals an explanation for initiation sites outside an origin. O'Donnell ME 1999 Molecular cell
Pre-steady state analysis of the assembly of wild type and mutant circular clamps of Escherichia coli DNA polymerase III onto DNA. O'Donnell ME 1998 The Journal of biological chemistry
Devoted to the lagging strand-the subunit of DNA polymerase III holoenzyme contacts SSB to promote processive elongation and sliding clamp assembly. O'Donnell ME 1998 The EMBO journal
ATP binding to the Escherichia coli clamp loader powers opening of the ring-shaped clamp of DNA polymerase III holoenzyme. O'Donnell ME 1998 The Journal of biological chemistry
Processivity of DNA polymerases: two mechanisms, one goal. O'Donnell ME 1998 Structure (London, England : 1993)
ATP hydrolysis catalyzed by human replication factor C requires participation of multiple subunits. O'Donnell ME 1998 Proceedings of the National Academy of Sciences of the United States of America
The influence of the proliferating cell nuclear antigen-interacting domain of p21(CIP1) on DNA synthesis catalyzed by the human and Saccharomyces cerevisiae polymerase delta holoenzymes. O'Donnell ME 1997 The Journal of biological chemistry
Crystal structure of the delta' subunit of the clamp-loader complex of E. coli DNA polymerase III. O'Donnell ME 1997 Cell
A complex consisting of human replication factor C p40, p37, and p36 subunits is a DNA-dependent ATPase and an intermediate in the assembly of the holoenzyme. O'Donnell ME 1997 The Journal of biological chemistry
DNA polymerase delta isolated from Schizosaccharomyces pombe contains five subunits. O'Donnell ME 1997 Proceedings of the National Academy of Sciences of the United States of America
Fidelity of Escherichia coli DNA polymerase III holoenzyme. The effects of beta, gamma complex processivity proteins and epsilon proofreading exonuclease on nucleotide misincorporation efficiencies. O'Donnell ME 1997 The Journal of biological chemistry
Lack of correlation between in vitro and in vivo replication of precisely defined benz-a-anthracene adducted DNAs. O'Donnell ME 1997 The Journal of biological chemistry
Thermus thermophilis dnaX homolog encoding gamma- and tau-like proteins of the chromosomal replicase. O'Donnell ME 1997 The Journal of biological chemistry
Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA. O'Donnell ME 1996 Cell
Replisome assembly reveals the basis for asymmetric function in leading and lagging strand replication. O'Donnell ME 1996 Cell
Dynamics of loading the beta sliding clamp of DNA polymerase III onto DNA. O'Donnell ME 1996 The Journal of biological chemistry
Mechanism of translesion DNA synthesis by DNA polymerase II. Comparison to DNA polymerases I and III core. O'Donnell ME 1996 The Journal of biological chemistry
Reconstitution of human replication factor C from its five subunits in baculovirus-infected insect cells. O'Donnell ME 1996 Proceedings of the National Academy of Sciences of the United States of America
Reconstitution of repair-gap UV mutagenesis with purified proteins from Escherichia coli: a role for DNA polymerases III and II. O'Donnell ME 1996 Proceedings of the National Academy of Sciences of the United States of America
In vitro reconstitution of human replication factor C from its five subunits. O'Donnell ME 1996 Proceedings of the National Academy of Sciences of the United States of America
Assembly of a chromosomal replication machine: two DNA polymerases, a clamp loader, and sliding clamps in one holoenzyme particle. I. Organization of the clamp loader. O'Donnell ME 1995 The Journal of biological chemistry
Assembly of a chromosomal replication machine: two DNA polymerases, a clamp loader, and sliding clamps in one holoenzyme particle. II. Intermediate complex between the clamp loader and its clamp. O'Donnell ME 1995 The Journal of biological chemistry
Assembly of a chromosomal replication machine: two DNA polymerases, a clamp loader, and sliding clamps in one holoenzyme particle. V. Four different polymerase-clamp complexes on DNA. O'Donnell ME 1995 The Journal of biological chemistry
Cycling of Escherichia coli DNA polymerase III from one sliding clamp to another: model for lagging strand. O'Donnell ME 1995 Methods in enzymology
Structural and functional similarities of prokaryotic and eukaryotic DNA polymerase sliding clamps. O'Donnell ME 1995 Nucleic acids research
DNA polymerase III holoenzyme: structure and function of a chromosomal replicating machine. O'Donnell ME 1995 Annu Rev Biochem
Assembly of a chromosomal replication machine: two DNA polymerases, a clamp loader, and sliding clamps in one holoenzyme particle. III. Interface between two polymerases and the clamp loader. O'Donnell ME 1995 The Journal of biological chemistry
An explanation for lagging strand replication: polymerase hopping among DNA sliding clamps. O'Donnell ME 1994 Cell
Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzyme. O'Donnell ME 1994 Proceedings of the National Academy of Sciences of the United States of America
Beta sliding clamp dynamics within E. coli DNA polymerase III holoenzyme. O'Donnell ME 1994 Ann N Y Acad Sci
holE, the gene coding for the theta subunit of DNA polymerase III of Escherichia coli: characterization of a holE mutant and comparison with a dnaQ (epsilon-subunit) mutant. O'Donnell ME 1994 Journal of bacteriology
DNA polymerase III accessory proteins. IV. Characterization of chi and psi. O'Donnell ME 1993 The Journal of biological chemistry
DNA polymerase III accessory proteins. V. Theta encoded by holE. O'Donnell ME 1993 The Journal of biological chemistry
DNA polymerase III accessory proteins. III. holC and holD encoding chi and psi. O'Donnell ME 1993 The Journal of biological chemistry
Sliding clamps of DNA polymerases. O'Donnell ME 1993 Journal of molecular biology
DNA polymerase III accessory proteins. II. Characterization of delta and delta'. O'Donnell ME 1993 The Journal of biological chemistry
DNA polymerase III accessory proteins. I. holA and holB encoding delta and delta'. O'Donnell ME 1993 The Journal of biological chemistry
The sliding clamp of DNA polymerase III holoenzyme encircles DNA. O'Donnell ME 1992 Molecular biology of the cell
Processive DNA synthesis by DNA polymerase II mediated by DNA polymerase III accessory proteins. O'Donnell ME 1992 The Journal of biological chemistry
Activity of the purified mutagenesis proteins UmuC, UmuD', and RecA in replicative bypass of an abasic DNA lesion by DNA polymerase III. O'Donnell ME 1992 Proceedings of the National Academy of Sciences of the United States of America
Three-dimensional structure of the beta subunit of E. coli DNA polymerase III holoenzyme: a sliding DNA clamp. O'Donnell ME 1992 Cell
Accessory protein function in the DNA polymerase III holoenzyme from E. coli. O'Donnell ME 1992 Bioessays
Analysis of the ATPase subassembly which initiates processive DNA synthesis by DNA polymerase III holoenzyme. O'Donnell ME 1991 The Journal of biological chemistry
Mechanism of the sliding beta-clamp of DNA polymerase III holoenzyme. O'Donnell ME 1991 The Journal of biological chemistry
Constitution of the twin polymerase of DNA polymerase III holoenzyme. O'Donnell ME 1991 The Journal of biological chemistry
Specificity and enzymatic mechanism of the editing exonuclease of Escherichia coli DNA polymerase III. O'Donnell ME 1991 The Journal of biological chemistry
Processive replication is contingent on the exonuclease subunit of DNA polymerase III holoenzyme. O'Donnell ME 1990 The Journal of biological chemistry
Total reconstitution of DNA polymerase III holoenzyme reveals dual accessory protein clamps. O'Donnell ME 1990 The Journal of biological chemistry
Interaction between the DNA polymerase and single-stranded DNA-binding protein (infected cell protein 8) of herpes simplex virus 1. O'Donnell ME 1987 The Journal of biological chemistry
Accessory proteins bind a primed template and mediate rapid cycling of DNA polymerase III holoenzyme from Escherichia coli. O'Donnell ME 1987 The Journal of biological chemistry
Processive replication of single-stranded DNA templates by the herpes simplex virus-induced DNA polymerase. O'Donnell ME 1987 The Journal of biological chemistry
Dynamics of DNA polymerase III holoenzyme of Escherichia coli in replication of a multiprimed template. O'Donnell ME 1985 The Journal of biological chemistry
Complete replication of templates by Escherichia coli DNA polymerase III holoenzyme. O'Donnell ME 1985 The Journal of biological chemistry
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