Error-prone DNA polymerases: novel structures and the benefits of infidelity.

Friedberg EC, Fischhaber PL, Kisker C
Cell (2001), Volume 107, Page 9
PubMed entry

Abstract:

Studies on several recently discovered error-prone DNA polymerases ...
Studies on several recently discovered error-prone DNA polymerases reveal novel structures that may explain the low fidelity of this general class of enzymes, a number of which are involved in the replicative bypass (translesion synthesis) of base damage in DNA.

Polymerases:

Dpo4

Topics:

Structure and Structure/Function

Note:

The review is largely based on the crystal structure of Dpo4.

Status:

new topics/pols set partial results complete validated

Results:

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