(+)-Myristinin A, a naturally occurring DNA polymerase beta inhibitor and potent DNA-damaging agent.

Maloney DJ, Deng JZ, Starck SR, Gao Z, Hecht SM
Journal of the American Chemical Society (2005), Volume 127, Page 4140
PubMed entry Publisher's site

Abstract:

The first stereoselective total synthesis of the naturally occurring ...
The first stereoselective total synthesis of the naturally occurring flavan myristinin A has been accomplished, as well as its biochemical evaluation. This synthesis verified the structural assignment and allowed for the determination of the absolute stereochemistry. Myristinin A exhibits biochemical activity both as a potent DNA-damaging agent and DNA polymerase beta inhibitor. Relaxation of supercoiled plasmid DNA was observed at picomolar concentrations, in addition to inhibition of polymerase beta at low micromolar concentrations.

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