Error-prone polymerase, DNA polymerase IV, is responsible for transient hypermutation during adaptive mutation in Escherichia coli.

Tompkins JD, Nelson JL, Hazel JC, Leugers SL, Stumpf JD, Foster PL
J Bacteriol (2003), Volume 185, Page 3469
PubMed entry Full article text

Abstract:

The frequencies of nonselected mutations among adaptive Lac(+) ...
The frequencies of nonselected mutations among adaptive Lac(+) revertants of Escherichia coli strains with and without the error-prone DNA polymerase IV (Pol IV) were compared. This frequency was more than sevenfold lower in the Pol IV-defective strain than in the wild-type strain. Thus, the mutations that occur during hypermutation are due to Pol IV.

Polymerases:

Eco Pol IV

Topics:

Other

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