Fatty acids selectively inhibit eukaryotic DNA polymerase activities in vitro.

Mizushina Y, Tanaka N, Yagi H, Kurosawa T, Onoue M, Seto H, Horie T, Aoyagi N, Yamaoka M, Matsukage A, Yoshida S, Sakaguchi K
Biochimica et biophysica acta (1996), Volume 1308, Page 256
PubMed entry

Abstract:

The in vitro relationship between eukaryotic DNA polymerases and fatty ...
The in vitro relationship between eukaryotic DNA polymerases and fatty acids was investigated. Some fatty acids strongly inhibited the activities of DNA polymerase alpha and/or beta in vitro. The kinetics of inhibition by linoleic acid showed that DNA polymerase alpha was non-competitively inhibited with respect to the DNA template and substrate (dTTP), while DNA polymerase beta was inhibited competitively with both DNA and substrate.

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