How are specialized (low-fidelity) eukaryotic polymerases selected and switched with high-fidelity polymerases during translesion DNA synthesis?


Specialized DNA polymerases are required in both prokaryotic and ...
Specialized DNA polymerases are required in both prokaryotic and eukaryotic cells for bypassing sites of template DNA damage that arrest high-fidelity DNA replication. Recent studies in the literature provide hints of the complexity of DNA switching between polymerases for translesion DNA synthesis (TLS) and those for normal DNA replication.



Health/Disease, Fidelity


The review compares processivity and termination of DNA synthesis opposite a CPD in template DNA by different polymerases including Dpo4 and describes role of “little finger” domain based on structural data for Dpo4.


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