How are specialized (low-fidelity) eukaryotic polymerases selected and switched with high-fidelity polymerases during translesion DNA synthesis?

Abstract:

Specialized DNA polymerases are required in both prokaryotic and eukaryotic cells for bypassing sites of template DNA damage that arrest high-fidelity DNA replication. Recent studies in the literature provide hints of the complexity of DNA switching between polymerases for translesion DNA synthesis (TLS) and those for normal DNA replication.

Polymerases:

Topics:

Health/Disease, Fidelity

Note:

The review compares processivity and termination of DNA synthesis opposite a CPD in template DNA by different polymerases including Dpo4 and describes role of “little finger” domain based on structural data for Dpo4.

Status:

new topics/pols set partial results complete validated

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