Heat mutagenesis in bacteriophage T4: the transversion pathway.

Abstract:

Heat induces transversions (as well as transitions) at G-C base pairs in bacteriophage T4. The target base for transversions is guanine,which is converted to a product which is sometimes replicated and transcribed as a pyrimidine.A model for this process is proposed in which the deoxyguanosine glycosidic bond migrates from N9 to N2: the resulting deoxyneoguanosine may pair with normal guanine to produce G-C leads to C-G transversions.

Polymerases:

T4

Topics:

Mutational Analysis

One line summary:

Model for GC->CG transversions

Status:

new topics/pols set partial results complete validated

Results:

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