The influence of neighboring base pairs upon base-pair substitution mutation rates.

Abstract:

The 2-aminopurine-induced transition, A.T --> G.C, was studied at particular sites in bacteriophage T4 as a function of the nearby base-pair composition of the DNA. Changing a base pair changed the transition rate at the adjacent base pair up to 23-fold, and at the next base pair by a lesser amount. Destabilization was achieved by replacing an A.T base pair by a G.C base pair.

Polymerases:

T4

Topics:

Mutational Analysis, Nucleotide Analogs / Template Lesions, Fidelity

Status:

new topics/pols set partial results complete validated

Results:

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