Structure and mechanism of DNA polymerases.

Abstract:

DNA polymerases are molecular motors directing the synthesis of DNA from nucleotides. All polymerases have a common architectural framework consisting of three canonical subdomains termed the fingers, palm, and thumb subdomains. Kinetically, they cycle through various states corresponding to conformational transitions, which may or may not generate force. In this review, we present and discuss the kinetic, structural, and single-molecule works that have contributed to our understanding of DNA polymerase function.

Polymerases:

Topics:

Other Enzymatic Activities, Structure and Structure/Function, Fidelity

Note:

The review discuss the kinetic, structural, and single-molecule studies of different DNA polymerases including Dpo4.

Status:

new topics/pols set partial results complete validated

Results:

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