HIV-1 RNase H: recent progress in an exciting, yet little explored, drug target.

Mini Rev Med Chem (2006), Volume 6, Page 727


HIV-1 reverse transcriptase-associated ribonuclease H (RNase H) is an attractive non traditional target for drug development which has been, so far, little explored. All drugs shown to inhibit HIV-1 RNase H are reported, including the recently described classes of compounds that interact with the metal ions in the active site.




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