Hydrogen bonding revisited: geometric selection as a principal determinant of DNA replication fidelity.

Polymerases:

T4

Topics:

Nucleotide Analogs / Template Lesions, Fidelity, Nucleotide Incorporation, Exonuclease Activity

One line summary:

Hydrogen bonding is not completely essential in the formation of base pairs, difluorotoulene proves this case as a non H-bonding structural facsimile of thymine

Status:

new topics/pols set partial results complete validated

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