Adriamycin and daunorubicin inhibition of mutant T4 DNA polymerases.


The anticancer drugs, adriamycin and daunorubicin, as well as two ...
The anticancer drugs, adriamycin and daunorubicin, as well as two other DNA reagents, ethidium bromide and 9-aminoacridine, all exert a differential inhibitory effect on nucleotide incorporation for purified DNA polymerases induced by mutant and wild-type bacteriophage T4. When compared with DNA polymerase of wild-type phage, antimutator enzymes are inhibited to a far greater extent and mutator enzymes to a lesser extent. In contrast, the polymerase-associated 3'-exonuclease activities of wild type and mutants are also inhibited by the compounds but nondifferentially.



Modulators/Inhibitors, Fidelity, Exonuclease Activity

One line summary:

DNA binding anti-cancer drugs Adriamycin and Daunorubicin inhibit antimutator T4 DNA polymerases more than mutator T4 DNA polymerases.


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