Crystal structure of the Pyrococcus horikoshii DNA primase-UTP complex: implications for the mechanism of primer synthesis.

Ito N, Nureki O, Shirouzu M, Yokoyama S, Hanaoka F
Genes to cells : devoted to molecular & cellular mechanisms (2003), Volume 8, Page 913
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Abstract:

In chromosomal DNA replication, DNA primase initiates the synthesis of ...
In chromosomal DNA replication, DNA primase initiates the synthesis of a dinucleotide on a single-stranded template DNA, and elongates it to form a primer RNA for the replicative DNA polymerase. Although the apo-structure of an archaeal primase has been reported, the mechanism of primer synthesis by the eukaryotic-type primase still remains to be elucidated.

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