Inhibitory effects of 2'-deoxy-5-styryluridine 5'-triphosphate analogs on retroviral reverse transcriptase and eukaryotic DNA polymerases.

Yamaguchi T, Izuta S, Suzuki M, Yoshida S, Matsukage A, Saneyoshi M
Nucleic acids symposium series (1992), Page 191
PubMed entry

Abstract:

Some sugar modified analogs of 2'-deoxy-E-5-styryluridine ...
Some sugar modified analogs of 2'-deoxy-E-5-styryluridine triphosphates were synthesized and examined for their inhibitory effects on eukaryotic DNA polymerases and HIV-1 reverse transcriptase. Among these compounds, 3'-azido-2',3'-dideoxy-E-5-styrylUTP (6) and 2',3'-dideoxy-E-5-styrylUTP (7) showed remarkable inhibitory effects on reverse transcriptase. The mode of action and the influence of the substituent at C-5 of 2',3'-dideoxyUTP analogs will be described.

Polymerases:

HIV RT

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