Competitive capacity of HIV-1 strains carrying M184I or Y181I drug-resistant mutations.

Li J, Li L, Li HP, Zhuang DM, Liu SY, Liu YJ, Bao ZY, Wang Z, Li JY
Chinese medical journal (2009), Volume 122, Page 1081
PubMed entry

Abstract:

Virus with nucleoside reverse transcriptase inhibitors (NRTIs) or ...
Virus with nucleoside reverse transcriptase inhibitors (NRTIs) or nonnucleoside reverse transcriptase inhibitors (NNRTIs) resistant mutations show different evolution tendencies when the anti-viral therapies are interrupted. Understanding the replication fitness of drug-resistant virus is important for the study of the prevalence of drug-resistance. For this purpose, we characterized the replication capacity of HIV-1 virus carrying lamivudine (3TC) or nevirapine (NVP) resistant mutations.

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