The Exonuclease Activity of the Yeast Mitochondrial DNA Polymerase γ Suppresses Mitochondrial DNA Deletions Between Short Direct Repeats in Saccharomyces cerevisiae.


The importance of mitochondrial DNA (mtDNA) deletions in the progeroid ...
The importance of mitochondrial DNA (mtDNA) deletions in the progeroid phenotype of exonuclease-deficient POLG mice has been intensely debated. We show that disruption of Mip1 exonuclease activity increases mtDNA deletions 160-fold, whereas disease-associated polymerase variants were mostly unaffected, suggesting that exonuclease activity is vital to avoid deletions during mtDNA replication.



Exonuclease Activity


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