The Exonuclease Activity of the Yeast Mitochondrial DNA Polymerase γ Suppresses Mitochondrial DNA Deletions Between Short Direct Repeats in Saccharomyces cerevisiae.

Abstract:

The importance of mitochondrial DNA (mtDNA) deletions in the progeroid phenotype of exonuclease-deficient POLG mice has been intensely debated. We show that disruption of Mip1 exonuclease activity increases mtDNA deletions 160-fold, whereas disease-associated polymerase variants were mostly unaffected, suggesting that exonuclease activity is vital to avoid deletions during mtDNA replication.

Polymerases:

Topics:

Exonuclease Activity

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