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Copeland WC

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Publications:

Title Authors Year Journal
Mitochondrial toxicity in hearts of CD-1 mice following perinatal exposure to AZT, 3TC, or AZT/3TC in combination. Copeland WC Environmental and molecular mutagenesis
The Exonuclease Activity of the Yeast Mitochondrial DNA Polymerase γ Suppresses Mitochondrial DNA Deletions Between Short Direct Repeats in Saccharomyces cerevisiae. Copeland WC 2013 Genetics
Translesion synthesis past acrolein-derived DNA adducts by human mitochondrial DNA polymerase γ Copeland WC 2013 The Journal of biological chemistry
Clinical and Molecular Features of POLG-Related Mitochondrial Disease. Copeland WC 2013 Cold Spring Harbor perspectives in biology
Balancing Antiviral Potency and Host Toxicity: Identifying a Nucleotide Inhibitor with an Optimal Kinetic Phenotype for HIV-1 Reverse Transcriptase. Copeland WC 2012 Molecular pharmacology
Defects in mitochondrial DNA replication and human disease. Copeland WC 2012 Critical reviews in biochemistry and molecular biology
A novel POLG gene mutation in a patient with SANDO. Copeland WC 2012 Journal of experimental and integrative medicine
Mutations in human DNA polymerase γ confer unique mechanisms of catalytic deficiency that mirror the disease severity in mitochondrial disorder patients. Copeland WC 2012 Human molecular genetics
RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity. Copeland WC 2012 Aging cell
Mitochondrial DNA replication and disease: insights from DNA polymerase gamma mutations. Copeland WC 2011 Cell Mol Life Sci
The Mechanism of Interaction of Human Mitochondrial DNA Polymerase γ with the Novel Nucleoside Reverse Transcriptase Inhibitor 4' -Ethynyl-2-Fluoro-2' -Deoxyadenosine Indicates a Low Potential for Host Toxicity. Copeland WC 2011 Antimicrobial agents and chemotherapy
The interface of transcription and DNA replication in the mitochondria. Copeland WC 2011 Biochimica et biophysica acta
Biochemical analysis of the G517V POLG variant reveals wild-type like activity. Copeland WC 2011 Mitochondrion
Human mitochondrial DNA polymerase γ exhibits potential for bypass and mutagenesis at UV-induced cyclobutane thymine dimers. Copeland WC 2011 The Journal of biological chemistry
Ribonucleotide discrimination and reverse transcription by the human mitochondrial DNA polymerase. Copeland WC 2011 The Journal of biological chemistry
Purification and functional characterization of human mitochondrial DNA polymerase gamma harboring disease mutations. Copeland WC 2010 Methods
A novel POLG gene mutation in 4 children with Alpers-like hepatocerebral syndromes. Copeland WC 2010 Archives of neurology
mip1 containing mutations associated with mitochondrial disease causes mutagenesis and depletion of mtDNA in Saccharomyces cerevisiae. Copeland WC 2010 Human molecular genetics
The mitochondrial DNA polymerase in health and disease. Copeland WC 2010 Subcell Biochem
Disease mutations in the human mitochondrial DNA polymerase thumb subdomain impart severe defects in mitochondrial DNA replication. Copeland WC 2009 The Journal of biological chemistry
R964C mutation of DNA polymerase gamma imparts increased stavudine toxicity by decreasing nucleoside analog discrimination and impairing polymerase activity. Copeland WC 2009 Antimicrob Agents Chemother
Mitochondrial DNA depletion and fatal infantile hepatic failure due to mutations in the mitochondrial polymerase gamma (POLG) gene A combined morphological/enzyme histochemical and immunocytochemical/biochemical and molecular genetic study. Copeland WC 2009 Journal of cellular and molecular medicine
Human DNA polymerase theta possesses 5'-dRP lyase activity and functions in single-nucleotide base excision repair in vitro. Copeland WC 2009 Nucleic acids research
DNA polymerase gamma and mitochondrial disease: understanding the consequence of POLG mutations. Copeland WC 2009 Biochimica et biophysica acta
Functional analysis of mutant mitochondrial DNA polymerase proteins involved in human disease. Copeland WC 2009 Methods in molecular biology (Clifton, N.J.)
Long patch base excision repair in mammalian mitochondrial genomes. Copeland WC 2008 The Journal of biological chemistry
Molecular and clinical genetics of mitochondrial diseases due to POLG mutations. Copeland WC 2008 Human mutation
The DNA polymerase gamma Y955C disease variant associated with PEO and parkinsonism mediates the incorporation and translesion synthesis opposite 7,8-dihydro-8-oxo-2'-deoxyguanosine. Copeland WC 2007 Human molecular genetics
Decreased mtDNA, oxidative stress, cardiomyopathy, and death from transgenic cardiac targeted human mutant polymerase gamma. Copeland WC 2007 Laboratory investigation; a journal of technical methods and pathology
Mitochondrial and nuclear DNA defects in Saccharomyces cerevisiae with mutations in DNA polymerase gamma associated with progressive external ophthalmoplegia. Copeland WC 2006 Hum Mol Genet
DNA polymerase gamma in mitochondrial DNA replication and repair. Copeland WC 2006 Chem Rev
Origins of human mitochondrial point mutations as DNA polymerase gamma-mediated errors. Copeland WC 2006 Mutation research
Modulation of the W748S mutation in DNA polymerase gamma by the E1143G polymorphismin mitochondrial disorders. Copeland WC 2006 Hum Mol Genet
Mutant POLG2 disrupts DNA polymerase gamma subunits and causes progressive external ophthalmoplegia. Copeland WC 2006 Am J Hum Genet
Antiretroviral nucleosides, deoxynucleotide carrier and mitochondrial DNA: evidence supporting the DNA pol gamma hypothesis. Copeland WC 2006 AIDS (London, England)
Molecular diagnosis of Alpers syndrome. Copeland WC 2006 Journal of hepatology
Consequences of mutations in human DNA polymerase gamma. Copeland WC 2005 Gene
The common A467T mutation in the human mitochondrial DNA polymerase (POLG) compromises catalytic efficiency and interaction with the accessory subunit. Copeland WC 2005 The Journal of biological chemistry
Mono-allelic POLG expression resulting from nonsense-mediated decay and alternative splicing in a patient with Alpers syndrome. Copeland WC 2005 DNA repair
Structure-function defects of human mitochondrial DNA polymerase in autosomal dominant progressive external ophthalmoplegia. Copeland WC 2004 Nature structural & molecular biology
Nucleotide incorporation by human DNA polymerase gamma opposite benzo[a]pyrene and benzo[c]phenanthrene diol epoxide adducts of deoxyguanosine and deoxyadenosine. Copeland WC 2004 Nucleic acids research
Structural determinants in human DNA polymerase gamma account for mitochondrial toxicity from nucleoside analogs. Copeland WC 2003 Journal of molecular biology
Mitochondrial toxicity of NRTI antiviral drugs: an integrated cellular perspective. Copeland WC 2003 Nature reviews. Drug discovery
Mutations in DNA polymerase gamma cause error prone DNA synthesis in human mitochondrial disorders. Copeland WC 2003 Acta Biochim Pol
DNA polymerase gamma in mitochondrial DNA replication and repair. Copeland WC 2003 ScientificWorldJournal
Active site mutation in DNA polymerase gamma associated with progressive external ophthalmoplegia causes error-prone DNA synthesis. Copeland WC 2002 The Journal of biological chemistry
Base composition at mtDNA boundaries suggests a DNA triple helix model for human mitochondrial DNA large-scale rearrangements. Copeland WC 2002 Molecular genetics and metabolism
Purification, separation, and identification of the human mtDNA polymerase with and without its accessory subunit. Copeland WC 2002 Methods in molecular biology (Clifton, N.J.)
The mitochondrial DNA polymerase as a target of oxidative damage. Copeland WC 2002 Nucleic acids research
Differential incorporation and removal of antiviral deoxynucleotides by human DNA polymerase gamma. Copeland WC 2001 The Journal of biological chemistry
The fidelity of human DNA polymerase gamma with and without exonucleolytic proofreading and the p55 accessory subunit. Copeland WC 2001 The Journal of biological chemistry
Mitochondrial dna depletion, oxidative stress, and mutation: mechanisms of dysfunction from nucleoside reverse transcriptase inhibitors. Copeland WC 2001 Laboratory investigation; a journal of technical methods and pathology
Eukaryotic DNA polymerases: proposal for a revised nomenclature. Copeland WC 2001 The Journal of biological chemistry
Mechanism of action of 1-beta-D-2,6-diaminopurine dioxolane, a prodrug of the human immunodeficiency virus type 1 inhibitor 1-beta-D-dioxolane guanosine. Copeland WC 2001 Antimicrobial agents and chemotherapy
The mitochondrial p55 accessory subunit of human DNA polymerase gamma enhances DNA binding, promotes processive DNA synthesis, and confers N-ethylmaleimide resistance. Copeland WC 1999 The Journal of biological chemistry
Interactions of DNA with human DNA primase monitored with photoactivatable cross-linking agents: implications for the role of the p58 subunit. Copeland WC 1999 Biochemistry
Effect of DNA polymerases and high mobility group protein 1 on the carrier ligand specificity for translesion synthesis past platinum-DNA adducts. Copeland WC 1999 Biochemistry
The accessory subunit of Xenopus laevis mitochondrial DNA polymerase gamma increases processivity of the catalytic subunit of human DNA polymerase gamma and is related to class II aminoacyl-tRNA synthetases. Copeland WC 1999 Molecular and cellular biology
Cloning and chromosomal mapping of the human DNA polymerase theta (POLQ), the eighth human DNA polymerase. Copeland WC 1999 Genomics
Characterization of the native and recombinant catalytic subunit of human DNA polymerase gamma: identification of residues critical for exonuclease activity and dideoxynucleotide sensitivity. Copeland WC 1998 Biochemistry
Identification of 5'-deoxyribose phosphate lyase activity in human DNA polymerase gamma and its role in mitochondrial base excision repair in vitro. Copeland WC 1998 Proceedings of the National Academy of Sciences of the United States of America
Immunohistochemical detection of human mtDNA polymerase gamma and of human mitochondrial transcription factor A in cytochrome-c-oxidase-deficient oxyphil cells of hyperfunctional parathyroids. Copeland WC 1998 Virchows Archiv : an international journal of pathology
Mitochondrial DNA polymerase gamma is expressed and translated in the absence of mitochondrial DNA maintenance and replication. Copeland WC 1996 Nucleic acids research
Cloning and characterization of the human mitochondrial DNA polymerase, DNA polymerase gamma. Copeland WC 1996 Genomics
Characterization of a new DNA polymerase from Schizosaccharomyces pombe: a probable homologue of the Saccharomyces cerevisiae DNA polymerase gamma. Copeland WC 1995 Gene
Rationale for mutagenesis of DNA polymerase active sites: DNA polymerase alpha. Copeland WC 1995 Methods in enzymology
Purification of mammalian DNA polymerases: DNA polymerase alpha. Copeland WC 1995 Methods in enzymology
Active site mapping of the catalytic mouse primase subunit by alanine scanning mutagenesis. Copeland WC 1995 The Journal of biological chemistry
Fidelity studies of the human DNA polymerase alpha. The most conserved region among alpha-like DNA polymerases is responsible for metal-induced infidelity in DNA synthesis. Copeland WC 1993 The Journal of biological chemistry
Mutational studies of human DNA polymerase alpha. Identification of residues critical for deoxynucleotide binding and misinsertion fidelity of DNA synthesis. Copeland WC 1993 The Journal of biological chemistry
Enzymatic characterization of the individual mammalian primase subunits reveals a biphasic mechanism for initiation of DNA replication. Copeland WC 1993 The Journal of biological chemistry
Initiation of simian virus 40 DNA replication requires the interaction of a specific domain of human DNA polymerase alpha with large T antigen. Copeland WC 1993 Molecular and cellular biology
Mutational studies of human DNA polymerase alpha. Serine 867 in the second most conserved region among alpha-like DNA polymerases is involved in primer binding and mispair primer extension. Copeland WC 1993 The Journal of biological chemistry
In vivo species specificity of DNA polymerase alpha. Copeland WC 1993 Mol Gen Genet
Mutational analysis of the human DNA polymerase alpha. The most conserved region in alpha-like DNA polymerases is involved in metal-specific catalysis. Copeland WC 1993 The Journal of biological chemistry
Selective action of 4'-azidothymidine triphosphate on reverse transcriptase of human immunodeficiency virus type 1 and human DNA polymerases alpha and beta. Copeland WC 1993 Biochemistry
Human DNA polymerases alpha and beta are able to incorporate anti-HIV deoxynucleotides into DNA. Copeland WC 1992 The Journal of biological chemistry
Catalytic subunit of human DNA polymerase alpha overproduced from baculovirus-infected insect cells. Structural and enzymological characterization. Copeland WC 1991 The Journal of biological chemistry
Human DNA polymerase alpha catalytic polypeptide binds ConA and RCA and contains a specific labile site in the N-terminus. Copeland WC 1990 Nucleic acids research

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