Structure and Function of an RNA-Reading Thermostable DNA Polymerase.

Abstract:

Unfaithful: The structure of a DNA-dependent DNA polymerase, whose parental ancestor has no significant reverse transcriptase activity, was obtained for the first time incorporating a nucleotide against an RNA template and then structurally characterized. The DNA polymerase variant has significant reverse transcriptase activity that allows its application in PCR-based molecular diagnostics.

Polymerases:

Topics:

Historical Protein Properties (MW, pI, ...), Structure and Structure/Function, Fidelity, Nucleotide Incorporation, Enzyme Substrate Interactions

Note:

unknown polymerase (no access to journal)

Status:

new topics/pols set partial results complete validated

Results:

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