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Marx A

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Publications:

Title Authors Year Journal
Application of the C4'-alkylated deoxyribose primer system (CAPS) in allele-specific real-time PCR for increased selectivity in discrimination of single nucleotide sequence variants. Marx A Biological chemistry
RNA pathogen detection with one-step reverse transcription PCR and strand-displacement based signal amplification. Marx A 2013 The Analyst
Expanding the Scope of Human DNA Polymerase λ and β Inhibitors. Marx A 2013 ACS chemical biology
Structure and Function of an RNA-Reading Thermostable DNA Polymerase. Marx A 2013 Angewandte Chemie (International ed. in English)
Snapshot of a DNA polymerase while incorporating two consecutive C5-modified nucleotides. Marx A 2013 Journal of the American Chemical Society
Improving bioorthogonal protein ubiquitylation by click reaction. Marx A 2013 Bioorganic & medicinal chemistry
Solution structure and conformational dynamics of deoxyxylonucleic acids (dXNA): an orthogonal nucleic acid candidate. Marx A 2012 Chemistry (Weinheim an der Bergstrasse, Germany)
Amino acid templating mechanisms in selection of nucleotides opposite abasic sites by a family a DNA polymerase. Marx A 2012 The Journal of biological chemistry
KlenTaq polymerase replicates unnatural base pairs by inducing a Watson-Crick geometry. Marx A 2012 Nature chemical biology
Interactions of non-polar and "Click-able" nucleotides in the confines of a DNA polymerase active site. Marx A 2012 Chemical communications (Cambridge, England)
Structures of KlenTaq DNA polymerase caught while incorporating C5-modified pyrimidine and C7-modified 7-deazapurine nucleoside triphosphates. Marx A 2012 Journal of the American Chemical Society
KlenTaq DNA polymerase adopts unique recognition states when encountering matched, mismatched, and abasic template sites: an NMR study. Marx A 2012 Chembiochem : a European journal of chemical biology
Learning from Directed Evolution: Thermus aquaticus DNA Polymerase Mutants with Translesion Synthesis Activity. Marx A 2011 Chembiochem : a European journal of chemical biology
Generation of a Mono-ubiquitinated PCNA Mimic by Click Chemistry. Marx A 2011 Chembiochem : a European journal of chemical biology
Human DNA polymerase beta mutations allowing efficient abasic site bypass. Marx A 2011 The Journal of biological chemistry
Small Molecule Inhibitors of Human DNA Polymerase λ. Marx A 2011 ACS chemical biology
Replication through an abasic DNA lesion: structural basis for adenine selectivity. Marx A 2010 The EMBO journal
One-step RNA pathogen detection with reverse transcriptase activity of a mutated thermostable Thermus aquaticus DNA polymerase. Marx A 2010 Biotechnology journal
A highly active DNA polymerase with a fluorous core. Marx A 2010 Angew Chem Int Ed Engl
A DNA polymerase with increased reactivity for ribonucleotides and C5-modified deoxyribonucleotides. Marx A 2010 Chembiochem
Replacing 32 proline residues by a noncanonical amino acid results in a highly active DNA polymerase. Marx A 2010 Journal of the American Chemical Society
Structural basis for the synthesis of nucleobase modified DNA by Thermus aquaticus DNA polymerase. Marx A 2010 Proceedings of the National Academy of Sciences of the United States of America
Structures of DNA polymerases caught processing size-augmented nucleotide probes. Marx A 2010 Angew Chem Int Ed Engl
Directed evolution of DNA polymerases: construction and screening of DNA polymerase mutant libraries. Marx A 2010 Current protocols in chemical biology
Steric constraints dependent on nucleobase pair orientation vary in different DNA polymerase active sites. Marx A 2009 Chembiochem
Enzymatic synthesis of perfluoroalkylated DNA. Marx A 2009 Bioorganic & medicinal chemistry
Novel strategies for the site-specific covalent labelling of nucleic acids. Marx A 2008 Chemical communications (Cambridge, England)
Varied active-site constraints in the klenow fragment of E. coli DNA polymerase I and the lesion-bypass Dbh DNA polymerase. Marx A 2008 Chembiochem
DNA polymerase-catalyzed DNA network growth. Marx A 2008 Journal of the American Chemical Society
New strategies for DNA polymerase library screening. Marx A 2008 Nucleic Acids Symp Ser (Oxf)
Opposed steric constraints in human DNA polymerase beta and E. coli DNA polymerase I. Marx A 2008 Journal of the American Chemical Society
Mutant DNA polymerase for improved detection of single-nucleotide variations in microarrayed primer extension. Marx A 2008 Chembiochem
DNA conjugation by Staudinger ligation. Marx A 2008 Nucleic acids symposium series (2004)
Directed DNA polymerase evolution: effects of mutations in motif C on the mismatch-extension selectivity of thermus aquaticus DNA polymerase. Marx A 2007 Chembiochem
Chemical biology of DNA polymerases: from selectivity to new functions. Marx A 2007 Nucleic acids symposium series (2004)
Evolving a thermostable DNA polymerase that amplifies from highly damaged templates. Marx A 2007 Angew Chem Int Ed Engl
Hydrophobic amino acid and single-atom substitutions increase DNA polymerase selectivity. Marx A 2007 Chemistry & biology
An efficient method for the construction of functionalized DNA bearing amino acid groups through cross-coupling reactions of nucleoside triphosphates followed by primer extension or PCR. Marx A 2007 Chemistry (Weinheim an der Bergstrasse, Germany)
Increased single-nucleotide discrimination in allele-specific polymerase chain reactions through primer probes bearing nucleobase and 2'-deoxyribose modifications. Marx A 2007 Chemistry (Weinheim an der Bergstrasse, Germany)
Increased single nucleotide discrimination in arrayed primer elongation by 4'C-modified primer probes. Marx A 2007 Chemical communications (Cambridge, England)
Lesion bypass activity of DNA polymerase A from the extremely radioresistant organism Deinococcus radiodurans. Marx A 2007 The Journal of biological chemistry
Evolving thermostable reverse transcriptase activity in a DNA polymerase scaffold. Marx A 2006 Angewandte Chemie (International ed. in English)
A new photoactive building block for investigation of DNA backbone interactions: photoaffinity labeling of human DNA polymerase beta. Marx A 2006 Chembiochem
Enhanced fidelity in mismatch extension by DNA polymerase through directed combinatorial enzyme design. Marx A 2005 Angewandte Chemie (International ed. in English)
4'C-ethynyl-thymidine acts as a chain terminator during DNA-synthesis catalyzed by HIV-1 reverse transcriptase. Marx A 2005 Bioorganic & medicinal chemistry letters
Tuning single nucleotide discrimination in polymerase chain reactions (PCRs): synthesis of primer probes bearing polar 4'-C-modifications and their application in allele-specific PCR. Marx A 2005 Chemistry (Weinheim an der Bergstrasse, Germany)
Synthesis of oligonucleotides bearing an arylamine modification in the C8-position of 2'-deoxyguanosine. Marx A 2005 Nucleosides, nucleotides & nucleic acids
Nucleotide analogues as probes for DNA polymerases. Marx A 2005 Cellular and molecular life sciences : CMLS
Increased single-nucleotide discrimination of PCR by primer probes bearing hydrophobic 4'C modifications. Marx A 2004 Chembiochem : a European journal of chemical biology
New light-sensitive nucleosides for caged DNA strand breaks. Marx A 2002 Chembiochem : a European journal of chemical biology
Varied DNA polymerase-substrate interactions in the nucleotide binding pocket. Marx A 2002 Chembiochem
A molecular beacon for quantitative monitoring of the DNA polymerase reaction in real-time. Marx A 2002 Angewandte Chemie (International ed. in English)
Implications of active site constraints on varied DNA polymerase selectivity. Marx A 2002 Journal of the American Chemical Society
Exploring the effects of active site constraints on HIV-1 reverse transcriptase DNA polymerase fidelity. Marx A 2002 The Journal of biological chemistry
Differential minor groove interactions between DNA polymerase and sugar backbone of primer and template strands. Marx A 2002 Journal of the American Chemical Society
DNA Polymerase Selectivity: Sugar Interactions Monitored with High-Fidelity Nucleotides This work was supported by a grant from the Deutsche Forschungsgemeinschaft. We thank Professor Dr. Michael Famulok for his continuing support. Marx A 2001 Angewandte Chemie (International ed. in English)
Association of acetylcholine receptor alpha-subunit gene expression in mixed thymoma with myasthenia gravis. Marx A 1999 Neurology
Probing interactions between HIV-1 reverse transcriptase and its DNA substrate with backbone-modified nucleotides. Marx A 1999 Chemistry & biology
4'-Acylated thymidine 5'-triphosphates: a tool to increase selectivity towards HIV-1 reverse transcriptase. Marx A 1998 Nucleic acids research
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