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Le Grice SF

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Publications:

Title Authors Year Journal
Inhibition of multi-drug resistant HIV-1 reverse transcriptase by nucleoside β-triphosphates. Le Grice SF 2011 Bioorganic & medicinal chemistry letters
Synthesis, activity, and structural analysis of novel α-hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H. Le Grice SF 2011 Journal of medicinal chemistry
Mutagenesis of the human immunodeficiency virus reverse transcriptase p51 subunit defines residues contributing to vinylogous urea inhibition of Ribonuclease H activity. Le Grice SF 2011 The Journal of biological chemistry
Reverse transcriptase in motion: conformational dynamics of enzyme-substrate interactions. Le Grice SF 2010 Biochimica et biophysica acta
Structure-activity analysis of vinylogous urea inhibitors of human immunodeficiency virus-encoded ribonuclease H. Le Grice SF 2010 Antimicrobial agents and chemotherapy
HIV-1 reverse transcriptase can simultaneously engage its DNA/RNA substrate at both DNA polymerase and RNase H active sites: implications for RNase H inhibition. Le Grice SF 2009 Journal of molecular biology
Examining the ribonuclease H primer grip of HIV-1 reverse transcriptase by charge neutralization of RNA/DNA hybrids. Le Grice SF 2008 Nucleic acids research
Mutations M184V and Y115F in HIV-1 reverse transcriptase discriminate against "nucleotide-competing reverse transcriptase inhibitors". Le Grice SF 2008 The Journal of biological chemistry
Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity. Le Grice SF 2008 ACS Chem Biol
Investigating the "steric gate" of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase by targeted insertion of unnatural amino acids. Le Grice SF 2007 Biochemistry
Attenuation of DNA replication by HIV-1 reverse transcriptase near the central termination sequence. Le Grice SF 2005 Biochemistry
Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones. Le Grice SF 2005 Nucleic acids research
A capillary electrophoretic assay for ribonuclease H activity. Le Grice SF 2004 Analytical biochemistry
Site- and subunit-specific incorporation of unnatural amino acids into HIV-1 reverse transcriptase. Le Grice SF 2004 Protein expression and purification
A fluorescence-based high-throughput screening assay for inhibitors of human immunodeficiency virus-1 reverse transcriptase-associated ribonuclease H activity. Le Grice SF 2003 Analytical biochemistry
Altering the RNase H primer grip of human immunodeficiency virus reverse transcriptase modifies cleavage specificity. Le Grice SF 2002 Biochemistry
Structural and functional properties of the HIV-1 RNA-tRNA(Lys)3 primer complex annealed by the nucleocapsid protein: comparison with the heat-annealed complex. Le Grice SF 2002 RNA (New York, N.Y.)
A novel interaction of tRNA(Lys,3) with the feline immunodeficiency virus RNA genome governs initiation of minus strand DNA synthesis. Le Grice SF 2001 The Journal of biological chemistry
Inhibition of the initiation of HIV-1 reverse transcription by 3'-azido-3'-deoxythymidine. Comparison with elongation. Le Grice SF 2000 The Journal of biological chemistry
Residues in the alphaH and alphaI helices of the HIV-1 reverse transcriptase thumb subdomain required for the specificity of RNase H-catalyzed removal of the polypurine tract primer. Le Grice SF 1999 The Journal of biological chemistry
Mutations in the primer grip region of HIV reverse transcriptase can increase replication fidelity. Le Grice SF 1999 The Journal of biological chemistry
Mutations within the primer grip region of HIV-1 reverse transcriptase result in loss of RNase H function. Le Grice SF 1997 The Journal of biological chemistry
Alanine-scanning mutations in the "primer grip" of p66 HIV-1 reverse transcriptase result in selective loss of RNA priming activity. Le Grice SF 1997 The Journal of biological chemistry
Effects of 3'-deoxynucleoside 5'-triphosphate concentrations on chain termination by nucleoside analogs during human immunodeficiency virus type 1 reverse transcription of minus-strand strong-stop DNA. Le Grice SF 1996 Journal of virology
Truncating alpha-helix E' of p66 human immunodeficiency virus reverse transcriptase modulates RNase H function and impairs DNA strand transfer. Le Grice SF 1995 The Journal of biological chemistry
HIV-1 reverse transcriptase-associated RNase H cleaves RNA/RNA in arrested complexes: implications for the mechanism by which RNase H discriminates between RNA/RNA and RNA/DNA. Le Grice SF 1995 The EMBO journal
An expanded model of replicating human immunodeficiency virus reverse transcriptase. Le Grice SF 1995 Biochemistry
Redesignation of the RNase D activity associated with retroviral reverse transcriptase as RNase H. Le Grice SF 1994 Journal of virology
Mutating the "primer grip" of p66 HIV-1 reverse transcriptase implicates tryptophan-229 in template-primer utilization. Le Grice SF 1994 The Journal of biological chemistry
Hydroxyl radical footprint analysis of human immunodeficiency virus reverse transcriptase-template.primer complexes. Le Grice SF 1993 Proceedings of the National Academy of Sciences of the United States of America
Subunit-selective mutagenesis indicates minimal polymerase activity in heterodimer-associated p51 HIV-1 reverse transcriptase. Le Grice SF 1991 The EMBO journal
Rapid purification of homodimer and heterodimer HIV-1 reverse transcriptase by metal chelate affinity chromatography. Le Grice SF 1990 Eur J Biochem

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